Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jost, PJ; Ruland, J.
Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications.
Blood. 2007; 109(7):2700-2707
Doi: 10.1182/blood-2006-07-025809
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Jost Philipp
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- Abstract:
- The transcription factor NF-kappaB is a tightly regulated positive mediator of T- and B-cell development, proliferation, and survival. The controlled activity of NF-kappaB is required for the coordination of physiologic immune responses. However, constitutive NF-kappaB activation can promote continuous lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lymphoma. Various molecular events lead to deregulation of NF-kappaB signaling in Hodgkin disease and a variety of T- and B-cell non-Hodgkin lymphomas either up-stream or downstream of the central IkappaB kinase. These alterations are prerequisites for lymphoma cell cycling and blockage of apoptosis. This review provides an overview of the NF-kappaB pathway and discusses the mechanisms of NF-kappaB deregulation in distinct lymphoma entities with defined aberrant pathways: Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), mucosa-associated lymphoid tissue (MALT) lymphoma, primary effusion lymphoma (PEL), and adult T-cell lymphoma/leukemia (ATL). In addition, we summarize recent data that validates the NF-kappaB signaling pathway as an attractive therapeutic target in T- and B-cell malignancies.
- Find related publications in this database (using NLM MeSH Indexing)
- Hodgkin Disease - physiopathology
- Humans -
- Leukemia-Lymphoma, Adult T-Cell - physiopathology
- Lymphocytes - physiology
- Lymphoma - genetics
- Lymphoma - physiopathology
- Lymphoma - therapy
- Lymphoma, B-Cell - physiopathology
- Lymphoma, B-Cell, Marginal Zone - genetics
- Lymphoma, B-Cell, Marginal Zone - physiopathology
- Lymphoma, Large B-Cell, Diffuse - physiopathology
- Models, Biological -
- NF-kappa B - physiology
- Oncogene Proteins, Viral - physiology
- Prognosis -
- Signal Transduction - physiology
- Translocation, Genetic -