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Jost, PJ; Ruland, J.
Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications.
Blood. 2007; 109(7):2700-2707 Doi: 10.1182/blood-2006-07-025809
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Führende Autor*innen der Med Uni Graz
Jost Philipp

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The transcription factor NF-kappaB is a tightly regulated positive mediator of T- and B-cell development, proliferation, and survival. The controlled activity of NF-kappaB is required for the coordination of physiologic immune responses. However, constitutive NF-kappaB activation can promote continuous lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lymphoma. Various molecular events lead to deregulation of NF-kappaB signaling in Hodgkin disease and a variety of T- and B-cell non-Hodgkin lymphomas either up-stream or downstream of the central IkappaB kinase. These alterations are prerequisites for lymphoma cell cycling and blockage of apoptosis. This review provides an overview of the NF-kappaB pathway and discusses the mechanisms of NF-kappaB deregulation in distinct lymphoma entities with defined aberrant pathways: Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), mucosa-associated lymphoid tissue (MALT) lymphoma, primary effusion lymphoma (PEL), and adult T-cell lymphoma/leukemia (ATL). In addition, we summarize recent data that validates the NF-kappaB signaling pathway as an attractive therapeutic target in T- and B-cell malignancies.
Find related publications in this database (using NLM MeSH Indexing)
Hodgkin Disease - physiopathology
Humans -
Leukemia-Lymphoma, Adult T-Cell - physiopathology
Lymphocytes - physiology
Lymphoma - genetics
Lymphoma - physiopathology
Lymphoma - therapy
Lymphoma, B-Cell - physiopathology
Lymphoma, B-Cell, Marginal Zone - genetics
Lymphoma, B-Cell, Marginal Zone - physiopathology
Lymphoma, Large B-Cell, Diffuse - physiopathology
Models, Biological -
NF-kappa B - physiology
Oncogene Proteins, Viral - physiology
Prognosis -
Signal Transduction - physiology
Translocation, Genetic -

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