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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Haidl, H; Schlagenhauf, A; Krebs, A; Plank, H; Wonisch, W; Fengler, V; Fiegl, A; Hörl, G; Koestenberger, M; Wagner, T; Tafeit, E; Cvirn, G; Hallström, S.
The anticoagulant effects of ethyl pyruvate in whole blood samples.
PLoS One. 2020; 15(10):e0240541-e0240541 Doi: 10.1371/journal.pone.0240541 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Cvirn Gerhard
Haidl Harald
Co-Autor*innen der Med Uni Graz
Fengler Vera
Hallström Seth
Hörl Gerd
Koestenberger Martin
Krebs Angelika
Schlagenhauf Axel
Tafeit Erwin
Wagner Thomas
Wonisch Willibald

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Ethyl pyruvate (EP), the ethyl ester of pyruvate, has proven antiinflammatory and antioxidative properties. Additionally, anticoagulant properties have been suggested recently. EP, therefore, is a potentially antiatherosclerotic drug. We aimed to investigate whether EP possesses antiplatelet and anticoagulant properties particularly in the physiological environment of whole blood. We investigated the effects of increasing concentrations of EP on platelet function, on the course of clot development, and on standard coagulation times. Additionally, clot ultrastructure using scanning electron microscopy was analysed. EP exerted significant antiplatelet actions: i) Impedance aggregometry amplitudes (11.7 ± 3.0 ohm, 0 μg/mL EP) dose dependently decreased (7.8 ± 3.1 ohm, 1000 μg/mL EP; -33.3%). ATP exocytosis (0.87 ± 0.24 nM, 0 μg/mL EP) measured by the luminiscent method dose-dependently decreased (0.56 ± 0.14 nM, 1000 μg/mL; -35.6%). ii) Closure times (104.4 ± 23.8 s, 0 μg/mL EP) using the Platelet function analyzer were dose-dependently prolonged (180.5 ± 82.5 s, 1000 μg/mL EP; +72.9%) using membranes coated with collagen/ADP. iii) Surface coverage (15.9 ± 5.1%, 0 μg/mL EP) dose-dependently decreased (9.0 ± 3.7%, 1000 μg/mL EP; -43.4%) using the Cone and Platelet analyzer. EP also exerted significant anticoagulant actions: Coagulation times (177.9 ± 37.8, 0 μg/mL EP) evaluated by means of thrombelastometry were dose-dependently prolonged (212.8 ± 57.7 s, 1000 μg/mL EP; +19.6%). Activated partial thromboplastin times (31.5 ± 1.8 s, 0 μg/mL EP) were dose-dependently prolonged (35.6 ± 2.3 s, 1000 μg/mL EP; +13.0%). Prothrombin times (0.94 ± 0.02 INR, 0 μg/mL EP) were dose-dependently prolonged (1.09 ± 0.04 INR, 1000 μg/mL EP; +16.0%). We found that EP possesses antiplatelet and anticoagulant properties in whole blood. Together with its proven anti-inflammatory and antioxidative properties, EP is a potentially antiatherogenic drug.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Anticoagulants - pharmacology
Blood Coagulation - drug effects
Healthy Volunteers -
Humans -
Male -
Middle Aged -
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - pharmacology
Pyruvates - pharmacology

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