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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Dalkner, N; Reininghaus, E; Schwalsberger, K; Rieger, A; Hamm, C; Pilz, R; Lenger, M; Queissner, R; Falzberger, VS; Platzer, M; Fellendorf, FT; Birner, A; Bengesser, SA; Weiss, EM; McIntyre, RS; Mangge, H; Reininghaus, B.
C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders.
Nutrients. 2020; 12(10): Doi: 10.3390/nu12103019 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Dalkner Nina
Reininghaus Eva
Co-Autor*innen der Med Uni Graz
Bengesser Susanne
Birner Armin
Fellendorf Frederike
Hamm Carlo
Lenger Melanie
Mangge Harald
Pilz Rene
Platzer Martina
Queissner Robert
Reininghaus Bernd
Rieger Alexandra

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Cognitive dysfunction is a prominent feature of psychiatric disorders. Studies have shown that systemic low-grade inflammation is crucial in the development of cognitive deficits across psychiatric disorders. The aim of this study was to further examine the role of inflammation and inflammatory mediators in cognitive function in psychiatric disorders. This study included 364 inpatients (53% females) with International Classification of Diseases (ICD)-10 F3 (affective disorders) and F4 (neurotic, stress-related, and somatoform disorders) diagnoses. The mean age was 52 years (22 to 69 years) and the median body mass index was 27.6. Cognitive function was assessed with the Color-Word Interference Test after Stroop and the Trail-Making Test A/B. Multiple linear regression models were calculated to assess the predictive value of C-reactive protein and the kynurenine/tryptophan ratio on cognitive function controlling for age, sex, education, premorbid verbal intelligence quotient illness duration, depressive symptoms, and obesity-related parameters (e.g., body mass index, high-density lipoprotein). Our data confirm that in patients with psychiatric disorders, C-reactive protein serum concentration is a relevant and important predictor of Trail-Making Test B performance, measuring cognitive flexibility. The effect size of this association did not change much after adding clinical and metabolic variables into the regression model. The kynurenine/tryptophan ratio was not related to cognitive test scores. The involvement of C-reactive protein as a peripheral inflammatory marker in cognitive flexibility and psychomotor processing speed in psychiatric illness can be concluded.

Find related publications in this database (Keywords)
C-reactive protein
psychomotor processing speed
cognitive flexibility
Trail-Making Test
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