Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dalkner, N; Reininghaus, E; Schwalsberger, K; Rieger, A; Hamm, C; Pilz, R; Lenger, M; Queissner, R; Falzberger, VS; Platzer, M; Fellendorf, FT; Birner, A; Bengesser, SA; Weiss, EM; McIntyre, RS; Mangge, H; Reininghaus, B.
C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders.
Nutrients. 2020; 12(10):
Doi: 10.3390/nu12103019
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- Führende Autor*innen der Med Uni Graz
- Dalkner Nina
- Reininghaus Eva
- Co-Autor*innen der Med Uni Graz
- Bengesser Susanne
- Birner Armin
- Fellendorf Frederike
- Hamm Carlo
- Lenger Melanie
- Mangge Harald
- Pilz Rene
- Platzer Martina
- Queissner Robert
- Reininghaus Bernd
- Rieger Alexandra
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- Abstract:
- Cognitive dysfunction is a prominent feature of psychiatric disorders. Studies have shown that systemic low-grade inflammation is crucial in the development of cognitive deficits across psychiatric disorders. The aim of this study was to further examine the role of inflammation and inflammatory mediators in cognitive function in psychiatric disorders. This study included 364 inpatients (53% females) with International Classification of Diseases (ICD)-10 F3 (affective disorders) and F4 (neurotic, stress-related, and somatoform disorders) diagnoses. The mean age was 52 years (22 to 69 years) and the median body mass index was 27.6. Cognitive function was assessed with the Color-Word Interference Test after Stroop and the Trail-Making Test A/B. Multiple linear regression models were calculated to assess the predictive value of C-reactive protein and the kynurenine/tryptophan ratio on cognitive function controlling for age, sex, education, premorbid verbal intelligence quotient illness duration, depressive symptoms, and obesity-related parameters (e.g., body mass index, high-density lipoprotein). Our data confirm that in patients with psychiatric disorders, C-reactive protein serum concentration is a relevant and important predictor of Trail-Making Test B performance, measuring cognitive flexibility. The effect size of this association did not change much after adding clinical and metabolic variables into the regression model. The kynurenine/tryptophan ratio was not related to cognitive test scores. The involvement of C-reactive protein as a peripheral inflammatory marker in cognitive flexibility and psychomotor processing speed in psychiatric illness can be concluded.
- Find related publications in this database (Keywords)
- inflammation
- C-reactive protein
- obesity
- cognition
- psychomotor processing speed
- cognitive flexibility
- Trail-Making Test