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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Blesl, A; Jüngst, C; Lammert, F; Fauler, G; Rainer, F; Leber, B; Feldbacher, N; Stromberger, S; Wildburger, R; Spindelböck, W; Fickert, P; Horvath, A; Stadlbauer, V.
Secondary Sclerosing Cholangitis in Critically Ill Patients Alters the Gut-Liver Axis: A Case Control Study.
Nutrients. 2020; 12(9): Doi: 10.3390/nu12092728 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Blesl Andreas
Co-Autor*innen der Med Uni Graz
Fauler Günter
Feldbacher Nicole
Fickert Peter
Horvath Angela
Leber Bettina
Rainer Florian
Spindelböck Walter Johann
Stadlbauer-Köllner Vanessa

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Secondary sclerosing cholangitis in critically ill patients (SC-CIP) occurs after long-term intensive care treatment. This study aimed to assess the gut-liver axis in SC-CIP. Stool microbiome composition, gut permeability, bacterial translocation and serum bile acid profiles of 18 SC-CIP patients compared to 11 patients after critical illness without liver disease (CIP controls), 21 patients with cirrhosis and 21 healthy controls were studied. 16S rDNA was isolated from stool and sequenced using the Illumina technique. Diamine oxidase, zonulin, soluble CD14 (sCD14) and lipopolysaccharide binding protein were measured in serum and calprotectin in stool. Serum bile acids were analyzed by high-performance liquid chromatography-mass spectrometry (HPLC-MS). Reduced microbiome alpha diversity and altered beta diversity were seen in SC-CIP, CIP controls and cirrhosis compared to healthy controls. SC-CIP patients showed a shift towards pathogenic taxa and an oralization. SC-CIP, CIP controls and cirrhotic patients presented with impaired gut permeability, and biomarkers of bacterial translocation were increased in SC-CIP and cirrhosis. Total serum bile acids were elevated in SC-CIP and cirrhosis and the bile acid profile was altered in SC-CIP, CIP controls and cirrhosis. In conclusions, observed alterations of the gut-liver axis in SC-CIP cannot solely be attributed to liver disease, but may also be secondary to long-term intensive care treatment.

Find related publications in this database (Keywords)
secondary sclerosing cholangitis
critical illness
gut permeability
bile acids
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