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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Reiter, A; Bengesser, SA; Hauschild, AC; Birkl-Töglhofer, AM; Fellendorf, FT; Platzer, M; Färber, T; Seidl, M; Mendel, LM; Unterweger, R; Lenger, M; Mörkl, S; Dalkner, N; Birner, A; Queissner, R; Hamm, C; Maget, A; Pilz, R; Kohlhammer-Dohr, A; Wagner-Skacel, J; Kreuzer, K; Schöggl, H; Amberger-Otti, D; Lahousen, T; Leitner-Afschar, B; Haybäck, J; Kapfhammer, HP; Reininghaus, E.
Interleukin-6 Gene Expression Changes after a 4-Week Intake of a Multispecies Probiotic in Major Depressive Disorder-Preliminary Results of the PROVIT Study.
Nutrients. 2020; 12(9): Doi: 10.3390/nu12092575 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Bengesser Susanne
Co-Autor*innen der Med Uni Graz
Amberger-Otti Daniela
Birner Armin
Dalkner Nina
Fellendorf Frederike
Hamm Carlo
Haybäck Johannes
Kapfhammer Hans-Peter
Kohlhammer-Dohr Alexandra
Kreuzer Kathrin
Lahousen-Luxenberger Theresa
Lenger Melanie
Maget Alexander
Mörkl Sabrina
Pilz Rene
Platzer Martina
Queissner Robert
Reininghaus Eva
Schöggl Helmut
Seidl Matthias
Unterweger Renate
Wagner-Skacel Jolana

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Major depressive disorder (MDD) is a prevalent disease, in which one third of sufferers do not respond to antidepressants. Probiotics have the potential to be well-tolerated and cost-efficient treatment options. However, the molecular pathways of their effects are not fully elucidated yet. Based on previous literature, we assume that probiotics can positively influence inflammatory mechanisms. We aimed at analyzing the effects of probiotics on gene expression of inflammation genes as part of the randomized, placebo-controlled, multispecies probiotics PROVIT study in Graz, Austria. Fasting blood of 61 inpatients with MDD was collected before and after four weeks of probiotic intake or placebo. We analyzed the effects on gene expression of tumor necrosis factor (TNF), nuclear factor kappa B subunit 1 (NFKB1) and interleukin-6 (IL-6). In IL-6 we found no significant main effects for group (F(1,44) = 1.33, p = ns) nor time (F(1,44) = 0.00, p = ns), but interaction was significant (F(1,44) = 5.67, p < 0.05). The intervention group showed decreasing IL-6 gene expression levels while the placebo group showed increasing gene expression levels of IL-6. Probiotics could be a useful additional treatment in MDD, due to their anti-inflammatory effects. Results of the current study are promising, but further studies are required to investigate the beneficial effects of probiotic interventions in depressed individuals.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Affect - drug effects
Austria - administration & dosage
Cognition - drug effects
Depressive Disorder, Major - blood, genetics, psychology
Female - administration & dosage
Gastrointestinal Microbiome - drug effects
Gene Expression - drug effects, genetics
Humans - administration & dosage
Interleukin-6 - blood, genetics
Male - administration & dosage
Probiotics - pharmacology

Find related publications in this database (Keywords)
gene expression
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