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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Horvath, A; Durdevic, M; Leber, B; di Vora, K; Rainer, F; Krones, E; Douschan, P; Spindelboeck, W; Durchschein, F; Zollner, G; Stauber, RE; Fickert, P; Stiegler, P; Stadlbauer, V.
Changes in the Intestinal Microbiome during a Multispecies Probiotic Intervention in Compensated Cirrhosis.
Nutrients. 2020; 12(6): Doi: 10.3390/nu12061874 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Durdevic Marija
Horvath Angela
Co-Autor*innen der Med Uni Graz
Baumann-Durchschein Franziska
Douschan Philipp
Fickert Peter
Leber Bettina
Rainer Florian
Spindelböck Walter Johann
Stadlbauer-Köllner Vanessa
Stauber Rudolf
Stiegler Philipp
Tatscher Elisabeth
Zollner Gernot

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Probiotics have been used in trials to therapeutically modulate the gut microbiome and have shown beneficial effects in cirrhosis. However, their effect on the microbiome of cirrhosis patients is not fully understood yet. Here, we tested the effects of a multispecies probiotic on microbiome composition in compensated cirrhosis. The gut microbiome composition of 58 patients with compensated cirrhosis from a randomized controlled trial who received a daily dose of multispecies probiotics or placebo for six months was analysed by 16S rRNA gene sequencing. Microbiome composition of patients who received probiotics was enriched with probiotic strains and the abundance of Faecalibacterium prausnitzii, Syntrophococcus sucromutans, Bacteroides vulgatus, Alistipes shahii and a Prevotella species was increased in the probiotic group compared to the placebo group. Patients who had microbiome changes in response to probiotic treatment also showed a significant increase in neopterin and a significant decrease in faecal zonulin levels after intervention, which was not observed in placebo-treated patients or patients with unchanged microbiome compositions. In conclusion, multispecies probiotics may enrich the microbiome of compensated cirrhotic patients with probiotic bacteria during a six-month intervention and beneficially change the residential microbiome and gut barrier function.

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gastrointestinal microbiome
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