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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Wolfsberger, C; Baik-Schneditz, N; Schwaberger, B; Binder-Heschl, C; Nina, H; Mileder, L; Bruckner, M; Avian, A; Urlesberger, B; Pichler, G.
Changes in peripheral muscle oxygenation measured with near-infrared spectroscopy in preterm neonates within the first 24 h after birth.
Physiol Meas. 2020; 41(7):075003-075003 Doi: 10.1088/1361-6579/ab998b
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Führende Autor*innen der Med Uni Graz
Pichler Gerhard
Wolfsberger Christina H.
Co-Autor*innen der Med Uni Graz
Avian Alexander
Baik-Schneditz Nariae
Binder-Heschl Corinna
Höller Nina
Krainer Marlies
Mileder Lukas Peter
Schwaberger Bernhard Christian
Urlesberger Berndt

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Near-infrared spectroscopy (NIRS) combined with venous occlusions enables peripheral-muscle oxygenation and perfusion monitoring. The aim of the present exploratory observational study was to evaluate peripheral-muscle oxygenation and perfusion during the first 24 h after birth in stable preterm neonates. Secondary outcome parameters of prospective observational studies were analysed. Preterm neonates with peripheral-muscle NIRS measurements combined with venous occlusion on the first day after birth were included. Neonates without circulatory support and without signs of infection/inflammation were included. Neonates were stratified in four groups according to their measurement time-point (6 h-periods) and matched 2:1 for gestational age ±1 week. For each group haemoglobin flow (Hbflow), oxygen-delivery (DO2), oxygen-consumption (VO2), fractional-oxygen-extraction (FOE), tissue-oxygenation-index (TOI) and mixed-venous-oxygenation (SvO2) were calculated. Neonates with measurements during the first 6-hour time period were compared to neonates with measurements of the following time periods. 40 preterm neonates (gestational age (median(IQR)): 33.5(32.5-34.1)weeks) measured during the first 6 h period after birth were compared to 20 preterm neonates measured in each of the following 6 h periods (period two: 33.7(33.1-34.3)weeks; period three: 34.1(33.2-34.6)weeks; period four: 33.8(32.6-34.6)weeks). Hbflow, DO2 and SvO2 were significantly higher in the second and third 6 h time period compared to the first 6 h period. VO2 did not change significantly during the first day after birth. FOE was significantly lower in the second, third and fourth time period compared to the first 6 h period. TOI showed a non-significant trend towards higher values in the third period compared to the first 6 h period. In preterm neonates Hbflow, DO2, SvO2 increased, FOE decreased and TOI showed a trend towards increase during the first day after birth, whereas VO2 did not change. Changes of peripheral-muscle oxygenation during the first day after birth in stable preterm neonates are different to already published changes thereafter.

Find related publications in this database (Keywords)
muscle oxygenation
muscle perfusion
near-infrared spectroscopy
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