Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eberhart, M; Grisold, A; Lavorato, M; Resch, E; Trobisch, A; Resch, B.
Extended-spectrum beta-lactamase (ESBL) producing Enterobacterales in stool surveillance cultures of preterm infants are no risk factor for necrotizing enterocolitis: a retrospective case-control study over 12 years.
Infection. 2020; 48(6):853-860
Doi: 10.1007/s15010-020-01453-0
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- Führende Autor*innen der Med Uni Graz
- Resch Bernhard
- Co-Autor*innen der Med Uni Graz
- Grisold Andrea
- Resch Elisabeth
- Trobisch Andreas
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- Abstract:
- PURPOSE: Microbial dysbiosis has been found preceding necrotizing enterocolitis (NEC) in preterm infants; thus, we aimed to investigate whether there is evidence that neonates with extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) positive stool cultures are at higher risk for NEC at the NICU. METHODS: We included very preterm inborn infants of ≤ 32 weeks of gestational age being fecal carriers of ESBL-E and compared them with 1:1 matched (gestational age, birth weight, gender and year) controls tested negative for ESBL-E in the stool between 2005 and 2016. An association with NEC was defined as the first detection of ESBL-E before or at the time of definite diagnosis of NEC. RESULTS: During the study period, we diagnosed 217 infants with a total of 270 ESBL-E. We identified ten different species with ESBL-producing Klebsiella oxytoca being the most common one (46%) followed by Klebsiella pneumoniae (19%), and Citrobacter freundii (17%). Ten out of 217 infants had any kind of NEC in the case group compared to two of the controls (p < 0.01), but only four cases with predefined criteria were associated with NEC ≥ stage IIa (1.8 vs. 0.5%, p = 0.089, OR 4.1, CI95% 0.45-36.6). NEC mortality rate was 2/8 (25%). CONCLUSIONS: We observed a threefold increase of ESBL-E in stool surveillance cultures during study time and germs were dominated by ESBL-producing Klebsiella spp. There was no evidence that preterm infants colonized with ESBL-E in the stool were at higher risk for definite NEC.
- Find related publications in this database (using NLM MeSH Indexing)
- Austria - epidemiology
- Case-Control Studies - administration & dosage
- Enterobacteriaceae - isolation & purification, metabolism
- Enterobacteriaceae Infections - epidemiology, microbiology
- Enterocolitis, Necrotizing - epidemiology, microbiology
- Feces - microbiology
- Female - administration & dosage
- Humans - administration & dosage
- Incidence - administration & dosage
- Infant, Newborn - administration & dosage
- Infant, Premature - administration & dosage
- Intensive Care Units, Neonatal - administration & dosage
- Male - administration & dosage
- Retrospective Studies - administration & dosage
- Risk Factors - administration & dosage
- beta-Lactamases - analysis
- Find related publications in this database (Keywords)
- ESBL
- Enterobacterales
- Epidemiology
- Necrotizing enterocolitis
- Preterm infant
- Risk