Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fandler-Höfler, S; Heschl, S; Kneihsl, M; Argüelles-Delgado, P; Niederkorn, K; Pichler, A; Deutschmann, H; Fazekas, F; Berghold, A; Enzinger, C; Gattringer, T.
Ventilation time and prognosis after stroke thrombectomy: the shorter, the better!
Eur J Neurol. 2020; 27(5):849-855 Doi: 10.1111/ene.14178 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Fandler-Höfler Simon
Gattringer Thomas
Co-Autor*innen der Med Uni Graz
Argüelles Delgado Placido Modesto
Berghold Andrea
Deutschmann Hannes
Enzinger Christian
Fazekas Franz
Heschl Stefan
Kneihsl Markus
Niederkorn Kurt
Pichler Alexander

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

The aim was to investigate the clinical impact of the duration of artificial ventilation in stroke patients receiving mechanical thrombectomy (MT) under general anaesthesia. All consecutive ischaemic stroke patients who had been treated at our centre with MT for anterior circulation large vessel occlusion under general anaesthesia were identified over an 8-year period. Ventilation time was analysed as a continuous variable and patients were grouped into extubation within 6 h ('early'), 6-24 h ('delayed') and >24 h ('late'). Favourable outcome was defined as modified Rankin Scale scores of 0-2 at 3 months post-stroke. Pneumonia rate and reasons for prolonged ventilation were also assessed. Amongst 447 MT patients (mean age 69.1 ± 13.3 years, 50.1% female), the median ventilation time was 3 h. 188 (42.6%) patients had a favourable 3-month outcome, which correlated with shorter ventilation time (Spearman's rho 0.39, P < 0.001). In patients extubated within 24 h, early compared to delayed extubation was associated with improved outcome (odds ratio 2.40, 95% confidence interval 1.53-3.76, P < 0.001). This was confirmed in multivariable analysis (P = 0.01). A longer ventilation time was associated with a higher rate of pneumonia during neurointensive care unit/stroke unit stay (early/delayed/late extubation: 9.6%/20.6%/27.7%, P < 0.01). Whilst stroke-associated complications represented the most common reasons for late extubation (>24 h), delayed extubation (6-24 h) was associated with admission outside of core working hours (P < 0.001). Prolonged ventilation time after stroke thrombectomy independently predicts unfavourable outcome at 3 months and is associated with increased pneumonia rates. Therefore, extubation should be performed as early as safely possible. © 2020 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

Find related publications in this database (Keywords)
endovascular procedures
intensive care
mechanical ventilation
neurocritical care
© Med Uni Graz Impressum