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Painold, A; Faber, PL; Reininghaus, EZ; Mörkl, S; Holl, AK; Achermann, P; Saletu, B; Saletu-Zyhlarz, G; Anderer, P; Dalkner, N; Birner, A; Bengesser, S; Kapfhammer, HP; Milz, P.
Reduced Brain Electric Activity and Functional Connectivity in Bipolar Euthymia: An sLORETA Source Localization Study.
Clin EEG Neurosci. 2020; 51(3):155-166 Doi: 10.1177/1550059419893472 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Painold Annamaria
Reininghaus Eva
Co-Autor*innen der Med Uni Graz
Bengesser Susanne
Birner Armin
Dalkner Nina
Holl Anna
Kapfhammer Hans-Peter
Mörkl Sabrina

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Bipolar disorder (BD) is a chronic illness with a relapsing and remitting time course. Relapses are manic or depressive in nature and intermitted by euthymic states. During euthymic states, patients lack the criteria for a manic or depressive diagnosis, but still suffer from impaired cognitive functioning as indicated by difficulties in executive and language-related processing. The present study investigated whether these deficits are reflected by altered intracortical activity in or functional connectivity between brain regions involved in these processes such as the prefrontal and the temporal cortices. Vigilance-controlled resting state EEG of 13 euthymic BD patients and 13 healthy age- and sex-matched controls was analyzed. Head-surface EEG was recomputed into intracortical current density values in 8 frequency bands using standardized low-resolution electromagnetic tomography. Intracortical current densities were averaged in 19 evenly distributed regions of interest (ROIs). Lagged coherences were computed between each pair of ROIs. Source activity and coherence measures between patients and controls were compared (paired t tests). Reductions in temporal cortex activity and in large-scale functional connectivity in patients compared to controls were observed. Activity reductions affected all 8 EEG frequency bands. Functional connectivity reductions affected the delta, theta, alpha-2, beta-2, and gamma band and involved but were not limited to prefrontal and temporal ROIs. The findings show reduced activation of the temporal cortex and reduced coordination between many brain regions in BD euthymia. These activation and connectivity changes may disturb the continuous frontotemporal information flow required for executive and language-related processing, which is impaired in euthymic BD patients.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Bipolar Disorder - physiopathology
Brain - physiopathology
Electroencephalography -
Female -
Humans -
Male -
Middle Aged -
Neural Pathways - physiopathology
Prefrontal Cortex - physiopathology
Retrospective Studies -
Signal Processing, Computer-Assisted -
Temporal Lobe - physiopathology
Young Adult -

Find related publications in this database (Keywords)
bipolar disorder
electroencephalography (EEG)
standardized low-resolution brain electromagnetic tomography (sLORETA)
intracortical lagged coherence
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