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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Mangge, H; Bengesser, S; Dalkner, N; Birner, A; Fellendorf, F; Platzer, M; Queissner, R; Pilz, R; Maget, A; Reininghaus, B; Hamm, C; Bauer, K; Rieger, A; Zelzer, S; Fuchs, D; Reininghaus, E.
Weight Gain During Treatment of Bipolar Disorder (BD)-Facts and Therapeutic Options.
Front Nutr. 2019; 6: 76-76. Doi: 10.3389/fnut.2019.00076 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Bengesser Susanne
Mangge Harald
Co-Autor*innen der Med Uni Graz
Bauer Konstantin
Birner Armin
Dalkner Nina
Fellendorf Frederike
Hamm Carlo
Maget Alexander
Pilz Rene
Platzer Martina
Queissner Robert
Reininghaus Bernd
Reininghaus Eva
Rieger Alexandra
Zelzer Sieglinde

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Bipolar disorder (BPD) is a mood disorder, which is characterized by alternating affective states, namely (hypo)mania, depression, and euthymia. Evidence is growing that BPD has indeed a biologic substrate characterized by chronic inflammation, oxidative stress, and disturbed energy metabolism. Apart from this, there is obviously a hereditary component of this disease with multi-genetic factors. Most probably a susceptibility threshold favors the outbreak of clinical disease after a cascade of stress events that remain to be elucidated in more detail. Evidence is also growing that weak points in brain energy metabolism contribute to outbreak and severity of BPD. Conventional psychopharmacologic therapy must be reassessed under the aspects of weight cycling and development of central obesity as a deterioration factor for a worse clinical course leading to early cardiovascular events in BPD subgroups.

Find related publications in this database (Keywords)
bipolar disorder
weight gain
oxidative stress
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