Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kessler, SM; Leber, B; Hoppstädter, J; Golob-Schwarzl, N; Hofer, EM; Schultheiss, CS; Mischinger, HJ; Liegl-Atzwanger, B; Lackner, C; Stiegler, P; Haybaeck, J.
Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs.
PLoS One. 2019; 14(5):e0214756-e0214756
Doi: 10.1371/journal.pone.0214756
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- Führende Autor*innen der Med Uni Graz
- Haybäck Johannes
- Stiegler Philipp
- Co-Autor*innen der Med Uni Graz
- Golob-Schwarzl Nicole
- Kessler Sonja
- Lackner Karoline
- Leber Bettina
- Liegl-Atzwanger Bernadette
- Mischinger Hans-Jörg
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- Abstract:
- Primary hepatic angiosarcoma is a rare tumor with poor prognosis. The aim of this study was to generate a new angiosarcoma model to improve research on hepatic angiosarcoma. Pigs sus scrofa were treated with different regimens of diethylnitrosamine (DENA). Tissues were analyzed by histology and immunohistochemistry. Serum parameters were determined. Angiosarcoma tissue was investigated for chromosomal aberrations by aCGH analysis. Animals of almost all different treatment regimens developed a multitude of variable liver lesions. Different tumor types such as granulation tissue type, cellular-like, hyalinization necrosis-like, angiosarcoma-like, dysplastic nodule-like, hepatocellular-like, glandular structure-like, and leiomyoma-like lesions were observed. Weekly treatment with 15 mg/kg for up to 52 weeks or a single shot of 200 mg/kg DENA led to the development of hepatic angiosarcomas. aCGH analysis of angiosarcoma tissue revealed increased alterations in tumors compared to non-tumorous tissue. Most of the chromosomal alterations were found on chromosomes 6, 7, 12, and 14. In this preliminary study treatment of sus scrofa with weekly injections of 15 mg/kg DENA results in a new model for primary hepatic angiosarcoma. This model may help to shed light on the pathomechanisms of primary hepatic angiosarcoma and might therefore open new treatment options.