Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mischinger, J; Fröhlich, E; Mannweiler, S; Meindl, C; Absenger-Novak, M; Hutterer, GC; Seles, M; Augustin, H; Chromecki, TF; Jesche-Chromecki, J; Pummer, K; Zigeuner, R.
Prognostic value of B7-H1, B7-H3 and the stage, size, grade and necrosis (SSIGN) score in metastatic clear cell renal cell carcinoma.
Cent European J Urol. 2019; 72(1): 23-31.
Doi: 10.5173/ceju.2018.1858
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- Führende Autor*innen der Med Uni Graz
- Mischinger Johannes
- Co-Autor*innen der Med Uni Graz
- Absenger-Novak Markus
- Augustin Herbert
- Chromecki Thomas
- Fröhlich Eleonore
- Hutterer Georg
- Jesche-Chromecki Johanna
- Mannweiler Sebastian
- Meindl Claudia
- Pummer Karl
- Seles Maximilian
- Zigeuner Richard
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- Abstract:
- We compared the potential prognostic impact of B7-H1 and B7-H3 glycoprotein expressions with the Mayo Clinic Stage, Size, Grade, and Necrosis (SSIGN) score in metastatic clear cell renal cell carcinoma (mccRCC) during a long term follow-up. We investigated 44 mccRCC patients, who underwent radical nephrectomy between 1995 and 2006 at a single tertiary academic center and received interferon therapy (IFNT) for at least three months. The SSIGN score was applied as a validated prediction outcome model. Representative tumor sections were immunostained with anti-B7-H3 and anti-B7-H1 antibodies. Hereafter, positive antigen-antibody reactions were measured using the Positive-Pixel-Count Algorithm of the Aperio-Technology Image Scope software. In total, 48% of patients were treated with cytoreductive nephrectomy and postoperative IFNT due to synchronous mccRCC, whereas 52% received IFNT after developing metachronous mccRCC. The SSIGN score was independently associated with a higher mortality risk. Patients with a SSIGN score ≤9 showed an extended 'nephrectomy to start of INFT'-interval (p = 0.02), less synchronous clinical metastases (p = 0.0002), as well as an increased median overall - (OS) or cancer-specific survival (CSS) (p = 0.01), respectively. Furthermore, B7-H3 expression levels of ≤16% were associated with an improved OS or CSS and correlated with a more frequent pathologic grade 1-2, as well as a longer 'nephrectomy to start of IFNT'-interval, respectively. B7-H1 expression patterns did not correlate with survival. The SSIGN score demonstrated the best prognostic performance. In contrast, B7-H3 expression patterns showed a low association with histopathological parameters, but predicted the cut-off-dependent impaired survival and in the future may define a cut-off to indicate checkpoint-inhibitor treatment.
- Find related publications in this database (Keywords)
- B7-H1
- B7-H3
- SSIGN score
- metastatic renal cell carcinoma
- Positive-Pixel-Count Algorithm