Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hamm, C; Queissner, R; Pilz, R; Birner, A; Platzer, M; Fellendorf, F; Maget, A; Bengesser, S; Dalkner, N; Reininghaus, B; Reininghaus, E.
[The relationship between intake of lithium and neuroradiological alterations in bipolar disorder. Are there predictors of clinical remission?]
Fortschr Neurol Psychiatr. 2019; 87(9):483-491
Doi: 10.1055/a-0637-1820
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- Führende Autor*innen der Med Uni Graz
- Hamm Carlo
- Co-Autor*innen der Med Uni Graz
- Bengesser Susanne
- Birner Armin
- Dalkner Nina
- Fellendorf Frederike
- Maget Alexander
- Pilz Rene
- Platzer Martina
- Queissner Robert
- Reininghaus Bernd
- Reininghaus Eva
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- Abstract:
- For avoiding affective episodes, patients with bipolar disorders are treated with mood stabilizers. Under that term, the substances lithium, valproic acid, lamotrigine and carbamazepine are included. In the light of upcoming new psychiatric concepts, the use of second generation antipsychotics is also taken into consideration in pharmacological treatment. In this review, the relation between brain structure and the use of lithium in bipolar disorders is examined. Therefore, results from MRI-, DTI-, SPECT-studies assessing this relation, were included.Most of the studies are cross-sectional and examined the effects of lithium. The latter is associated with increased cortical and sub-cortical gray matter volume and ameliorative white matter microstructure. 7-lithium spectroscopy showed a significant difference in brain-lithium concentrations between remitted and non-remitted patients.There are preclinical studies reporting induction of promitotic and antiapoptotic effects by lithium. This literature underpins the hypothesis of lithium-induced neurogenesis. However, osmotic and physical effects of lithium could also explain the demonstrated volume gain in bipolar human brain.Cross-sectional design and small patient groups are typical limitations of numerous studies included in this review.Notably, with the 7-lithium spectroscopy of the central nervous system, new perspectives in clinical research to clarify pharmacokinetic differences between remitted and non-remitted bipolar patients can be established in future. © Georg Thieme Verlag KG Stuttgart · New York.
- Find related publications in this database (using NLM MeSH Indexing)
- Antimanic Agents - analysis
- Antimanic Agents - chemistry
- Antimanic Agents - therapeutic use
- Antipsychotic Agents - analysis
- Antipsychotic Agents - chemistry
- Antipsychotic Agents - therapeutic use
- Bipolar Disorder - drug therapy
- Bipolar Disorder - pathology
- Bipolar Disorder - psychology
- Cross-Sectional Studies -
- Humans -
- Lithium Compounds - analysis
- Lithium Compounds - chemistry
- Lithium Compounds - therapeutic use
- Remission Induction -
- Find related publications in this database (Keywords)
- Bipolar disorders
- Lithium
- MRI
- DTI
- MR-Spectroscopy