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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Matzer, F; Fazekas, C; Vajda, C; Pilz, S; Schwetz, V; Trummer, C; Pandis, M; Tomaschitz, A; Petsch, I; Obermayer-Pietsch, B; Pieber, T; Kapfhammer, HP.
Association of allostatic load with health-related quality of life in patients with arterial hypertension: a cross-sectional analysis.
Swiss Med Wkly. 2018; 148(12):w14689-w14689 Doi: 10.4414/smw.2018.14689 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Fazekas Christian
Matzer Franziska
Co-Autor*innen der Med Uni Graz
Kapfhammer Hans-Peter
Obermayer-Pietsch Barbara
Pandis Marlene
Pieber Thomas
Pilz Stefan
Theiler-Schwetz Verena
Trummer Christian
Vajda Christian

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Allostatic load (AL), as a marker of cumulative stress, is associated with higher morbidity and mortality, and reduced health-related quality of life (HrQoL) in healthy adults. In patients with hypertension, AL and its association with HrQoL have not been investigated. Therefore, this study aimed to (1) explore AL in a cohort of hypertensive patients and to (2) determine its association with HrQoL, while controlling for other health-related variables. Cross-sectional data from the Styrian Hypertension Study were analysed and included 126 participants (50% female) with a history of arterial hypertension; the mean age was 60.9 years (standard deviation 9.9). AL was derived from a set of 10 biomarkers including neurophysiological, neuroendocrine, metabolic, cardiovascular and inflammatory parameters. The 36-Item Short Form Health Survey (SF-36) was administered for assessment of HrQoL. Additional health-related variables included sociodemographic data, lifestyle factors and comorbidities. Calculation of AL resulted in sum scores based on 10 binary variables, which were used to categorise patients as either “low AL” (<3) or “high AL” (≥3). Multivariate adjusted analyses revealed that higher AL was associated with better HrQoL with regard to the mental health domain F(1,1243) = 7.017; p = 0.009). All other components of HrQoL were not related to AL. In contrast to results in healthy populations, we found a positive association between AL and the mental health domain of HrQoL. This finding suggests a specific coping pattern among a subgroup of hypertensive patients, possibly influencing their clinical management and outcome.
Find related publications in this database (using NLM MeSH Indexing)
Adaptation, Psychological -
Aged -
Aged, 80 and over -
Allostasis -
Blood Pressure - physiology
Cohort Studies -
Comorbidity -
Cross-Sectional Studies -
Female -
Heart Rate - physiology
Humans -
Hypertension - epidemiology
Life Style -
Male -
Mental Health -
Middle Aged -
Quality of Life - psychology
Socioeconomic Factors -
Surveys and Questionnaires -

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