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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Bengesser, SA; Mörkl, S; Painold, A; Dalkner, N; Birner, A; Fellendorf, FT; Platzer, M; Queissner, R; Hamm, C; Maget, A; Pilz, R; Rieger, A; Wagner-Skacel, J; Reininghaus, B; Kapfhammer, HP; Petek, E; Kashofer, K; Halwachs, B; Holzer, P; Waha, A; Reininghaus, EZ.
Epigenetics of the molecular clock and bacterial diversity in bipolar disorder.
Psychoneuroendocrinology. 2019; 101(6):160-166 Doi: 10.1016/j.psyneuen.2018.11.009
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Führende Autor*innen der Med Uni Graz
Bengesser Susanne
Mörkl Sabrina
Co-Autor*innen der Med Uni Graz
Birner Armin
Dalkner Nina
Fellendorf Frederike
Halwachs-Wenzl Bettina
Hamm Carlo
Holzer Peter
Kapfhammer Hans-Peter
Kashofer Karl
Maget Alexander
Painold Annamaria
Petek Erwin
Pilz Rene
Platzer Martina
Queissner Robert
Reininghaus Bernd
Reininghaus Eva
Rieger Alexandra
Wagner-Skacel Jolana
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Abstract:
Objectives The gut microbiome harbors substantially more genetic material than our body cells and has an impact on a huge variety of physiological mechanisms including the production of neurotransmitters and the interaction with brain functions through the gut-brain-axis. Products of microbiota can affect methylation according to preclinical studies. The current investigation aimed at analyzing the correlation between gut microbiome diversity and the methylation of the clock gene ARNTL in individuals with Bipolar Disorder (BD). Methods Genomic DNA was isolated from fasting blood of study participants with BD (n = 32). The methylation analysis of the ARNTL CG site cg05733463 was performed by bisulfite treatment of genomic DNA with the Epitect kit, PCR and pyrosequencing. Additionally, DNA was extracted from stool samples and subjected to 16S rRNA sequencing. QIIME was used to analyze microbiome data. Results Methylation status of the ARNTL CpG position cg05733463 correlated significantly with bacterial diversity (Simpson index: r= -0.389, p =  0.0238) and evenness (Simpson evenness index: r= -0.358, p =  0.044). Furthermore, bacterial diversity differed significantly between euthymia and depression (F(1,30) = 4.695, p =  0.039). Discussion The results of our pilot study show that bacterial diversity differs between euthymia and depression. Interestingly, gut microbiome diversity and evenness correlate negatively with methylation of ARNTL, which is known to regulate monoamine oxidase A transcription. We propose that alterations in overall diversity of the gut microbiome represent an internal environmental factor that has an epigenetic impact on the clock gene ARNTL which is thought to be involved in BD pathogenesis. Copyright © 2018. Published by Elsevier Ltd.
Find related publications in this database (using NLM MeSH Indexing)
ARNTL Transcription Factors - genetics
ARNTL Transcription Factors - metabolism
Adult -
Bipolar Disorder - genetics
Bipolar Disorder - microbiology
Bipolar Disorder - physiopathology
Circadian Rhythm - genetics
Circadian Rhythm - physiology
DNA Methylation -
Depression - genetics
Depressive Disorder - genetics
Epigenesis, Genetic - genetics
Epigenomics - methods
Female -
Gastrointestinal Microbiome - genetics
Gastrointestinal Microbiome - physiology
Humans -
Male -
Microbiota - genetics
Middle Aged -
Pilot Projects -
RNA, Ribosomal, 16S - genetics

Find related publications in this database (Keywords)
Gut microbiome
Epigenetics
ARNTL
Bipolar disorder
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