Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Klec, C; Prinz, F; Pichler, M.
Involvement of the long noncoding RNA NEAT1 in carcinogenesis.
Mol Oncol. 2019; 13(1):46-60
Doi: 10.1002/1878-0261.12404
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- Führende Autor*innen der Med Uni Graz
- Klec Christiane
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Prinz Felix
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- Abstract:
- Altered expression levels of the long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) have been reported in different types of cancer. More than half of the NEAT1 studies in cancer have been published within the last 2 years. In this review, we discuss very recent developments and insights into NEAT1 contribution to carcinogenesis. Summarizing the literature, it becomes obvious that NEAT1 is a lncRNA highly de-/upregulated in a variety of cancer entities, in which it primarily acts as a competing endogenous RNA (ceRNA) which sponges tumor-suppressive microRNA (miRNA). The sponged miRNA lose their ability to degrade, silence, or hamper translation of their downstream-mostly oncogenic-target transcripts, ultimately promoting carcinogenesis. This role of NEAT1 function in tumorigenesis suggests it may be a prognostic biomarker as well as potential therapeutic target, pending the completion of further studies into the underlying mechanisms. © 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
- Find related publications in this database (Keywords)
- cancer
- ceRNA
- lncRNA
- miRNA
- NEAT1