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Steiner, B; Dimai, HP; Steiner, H; Cirar, S; Fahrleitner-Pammer, A.
Prescreening for Osteoporosis With Quantitative Ultrasound in Postmenopausal White Women.
J Ultrasound Med. 2019; 38(6):1553-1559 Doi: 10.1002/jum.14844 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Steiner Bernhard
Co-Autor*innen der Med Uni Graz
Dimai Hans Peter
Fahrleitner-Pammer Astrid

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Calcaneal quantitative ultrasound (QUS) is a readily accessible and radiation-free alternative to dual-energy x-ray absorptiometry (DXA) for assessing bone mineral density (BMD). Results obtained from QUS measurement cannot directly be compared to DXA, since these techniques capture different bone-specific parameters. To identify individuals who are likely to have osteoporosis by DXA, device-specific thresholds have to be defined for QUS. This cross-sectional study evaluated the accuracy of QUS to identify postmenopausal women with osteoporosis, defined as a T score of -2.5 SDs or lower by DXA, and to calculate device-specific cutoff values for the QUS device investigated. We assessed BMD at the lumbar spine, bilateral femoral neck, and total hip sites with DXA and QUS parameters of the right and left calcanei in a cohort of 245 postmenopausal treatment-naïve women between 40 and 82 years. Correlation coefficients for BMD and QUS parameters were calculated. Receiver operating characteristic curves were generated, and areas under the curves (AUCs) were evaluated. Cutoff values for QUS were defined. Calcaneal QUS had the ability to identify postmenopausal women with a T score of -2.5 or lower at the right hip (AUC, 0.887) and left femoral neck (AUC, 0.824). Cutoff values for the QUS T scores at the right (-1.455) and left (-1.480) calcanei were defined for screening purposes. This study provides insights into the comparative performance of QUS with DXA. Considering the diagnostic accuracy of this modality in comparison to DXA, it can be recommended as a prescreening tool to reduce the number of DXA screenings. © 2018 The Authors. Journal of Ultrasound in Medicine published by Wiley Periodicals, Inc. on behalf of the American Institute of Ultrasound in Medicine.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Bone Density - physiology
Cross-Sectional Studies -
European Continental Ancestry Group - statistics & numerical data
Evaluation Studies as Topic -
Female -
Humans -
Middle Aged -
Osteoporosis - diagnostic imaging
Osteoporosis - physiopathology
Postmenopause -
Reproducibility of Results -
Sensitivity and Specificity -
Ultrasonography - methods

Find related publications in this database (Keywords)
bone mineral density
dual-energy x-ray absorptiometry
postmenopausal women
quantitative ultrasound
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