Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Mörkl, S; Lackner, S; Meinitzer, A; Mangge, H; Lehofer, M; Halwachs, B; Gorkiewicz, G; Kashofer, K; Painold, A; Holl, AK; Bengesser, SA; Müller, W; Holzer, P; Holasek, SJ.
Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women.
Eur J Nutr. 2018;
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Autor/innen der Med Uni Graz:
Bengesser Susanne
Gorkiewicz Gregor
Halwachs-Wenzl Bettina
Holasek Sandra Johanna
Holl Anna Katharina
Holzer Peter
Kashofer Karl
Lackner Sonja
Mangge Harald
Meinitzer Andreas
Mörkl Sabrina
Müller Wolfram
Painold Annamaria
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Abstract:
Increased gut permeability causes the trespass of antigens into the blood stream which leads to inflammation. Gut permeability reflected by serum zonulin and diversity of the gut microbiome were investigated in this cross-sectional study involving female study participants with different activity and BMI levels. 102 women were included (BMI range 13.24-46.89 kg m-2): Anorexia nervosa patients (n = 17), athletes (n = 20), normal weight (n = 25), overweight (n = 21) and obese women (n = 19). DNA was extracted from stool samples and subjected to 16S rRNA gene analysis (V1-V2). Quantitative Insights Into Microbial Ecology (QIIME) was used to analyze data. Zonulin was measured with ELISA. Nutrient intake was assessed by repeated 24-h dietary recalls. We used the median of serum zonulin concentration to divide our participants into a "high-zonulin" (> 53.64 ng/ml) and "low-zonulin" (< 53.64 ng/ml) group. The alpha-diversity (Shannon Index, Simpson Index, equitability) and beta-diversity (unweighted and weighted UniFrac distances) of the gut microbiome were not significantly different between the groups. Zonulin concentrations correlated significantly with total calorie-, protein-, carbohydrate-, sodium- and vitamin B12 intake. Linear discriminant analysis effect size (LEfSe) identified Ruminococcaceae (LDA = 4.163, p = 0.003) and Faecalibacterium (LDA = 4.151, p = 0.0002) as significantly more abundant in the low zonulin group. Butyrate-producing gut bacteria such as Faecalibacteria could decrease gut permeability and lower inflammation. The diversity of the gut microbiota in women does not seem to be correlated with the serum zonulin concentration. Further interventional studies are needed to investigate gut mucosal permeability and the gut microbiome in the context of dietary factors.

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