Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mileder, LP; Müller, T; Baik-Schneditz, N; Pansy, J; Schwaberger, B; Binder-Heschl, C; Urlesberger, B; Pichler, G.
Influence of ductus arteriosus on peripheral muscle oxygenation and perfusion in neonates.
Physiol Meas. 2017; 39(1):015003
Doi: 10.1088/1361-6579/aa9c3b
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mileder Lukas Peter
- Co-Autor*innen der Med Uni Graz
- Baik-Schneditz Nariae
- Binder-Heschl Corinna
- Pansy Jasmin
- Pichler Gerhard
- Schwaberger Bernhard Christian
- Urlesberger Berndt
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- Abstract:
- OBJECTIVE: In neonates, a patent ductus arteriosus (DA) may be associated with severe complications. We used near-infrared spectroscopy (NIRS) with venous occlusion to investigate the influence of an open DA on peripheral muscle oxygenation/perfusion in preterm neonates. APPROACH: We analyzed secondary outcome parameters collected as part of prospective observational studies. NIRS measurements were performed between the first and third day of life. Arterial oxygen saturation (SaO2) and heart rate (HR) were monitored by pulse oximetry on the ipsilateral foot. Venous occlusion was performed with a blood pressure cuff on the thigh. Tissue oxygenation index (TOI), hemoglobin flow (Hbflow), oxygen delivery (DO2), oxygen consumption (VO2), mixed venous oxygenation (SvO2), and fractional oxygen extraction (FOE) were assessed. Echocardiography was performed within plus/minus 6 h from NIRS measurements. MAIN RESULTS: Twenty-eight neonates were included. In neonates with open DA (n = 15), the FOE was significantly higher (p = 0.046). DA diameter correlated negatively with SvO2 (r = -0.413, p = 0.032) and positively with FOE (r = 0.417, p = 0.030). In neonates with open DA, SaO2 was significantly lower (p = 0.041). DA diameter correlated negatively with SaO2 (r = -0.377, p = 0.048) and positively with HR (r = 0.489, p = 0.010). SIGNIFICANCE: Our results showed that an open DA influences peripheral muscle oxygenation in preterm neonates.
- Find related publications in this database (using NLM MeSH Indexing)
- Ductus Arteriosus - physiology
- Female - administration & dosage
- Hemoglobins - metabolism
- Humans - administration & dosage
- Infant, Newborn - administration & dosage
- Male - administration & dosage
- Muscles - blood supply, metabolism
- Oxygen - metabolism
- Find related publications in this database (Keywords)
- neonates
- ductus arteriosus
- muscle oxygenation
- muscle perfusion
- near-infrared spectroscopy