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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Kneihsl, M; Niederkorn, K; Deutschmann, H; Enzinger, C; Poltrum, B; Fischer, R; Thaler, D; Hermetter, C; Wünsch, G; Fazekas, F; Gattringer, T.
Increased middle cerebral artery mean blood flow velocity index after stroke thrombectomy indicates increased risk for intracranial hemorrhage.
J Neurointerv Surg. 2018; 10(9):882-887 Doi: 10.1136/neurintsurg-2017-013617
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Führende Autor*innen der Med Uni Graz
Gattringer Thomas
Kneihsl Markus
Co-Autor*innen der Med Uni Graz
Deutschmann Hannes
Enzinger Christian
Fazekas Franz
Fischer Renate
Hermetter Christina
Niederkorn Kurt
Poltrum Birgit
Thaler Daniela
Wünsch Gerit

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Cerebral hyperperfusion has been related to the risk of intracranial hemorrhage (ICH) in stroke patients after vessel recanalization therapy. We hypothesized that after successful mechanical thrombectomy for acute anterior circulation stroke, hemodynamics detectable by transcranial Duplex (TCD) sonography would vary, and that increased blood flow velocities would be associated with ICH. We retrospectively identified all ischemic stroke patients with successful endovascular recanalization for anterior circulation vessel occlusion (Thrombolysis in Cerebral Infarction 2b-3) between 2010 and 2017. We reviewed their postinterventional TCD examinations for mean blood flow (MBF) velocities of the recanalized and contralateral middle cerebral artery (MCA) and searched for an association with postinterventional ICH and clinical outcome. 123 stroke patients (mean age 63±14 years, 40% women) with successful anterior circulation thrombectomy were analyzed. Of those, 18 patients had postinterventional ICH. ICH patients had an increased MCA MBF velocity index (=MBF velocity of the recanalized divided by the contralateral MCA) compared with non-ICH patients (1.32±0.39 vs 1.02±0.32, P<0.001). In multivariate analysis, a higher MCA MBF velocity index was associated with postinterventional ICH and poor 90 day outcome. A high MCA MBF velocity index on TCD after successful recanalization therapy for anterior circulation stroke indicates a risk for postinterventional ICH and worse prognosis. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

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