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Langsenlehner, U; Krippl, P; Renner, W; Yazdani-Biuki, B; Eder, T; Köppel, H; Wascher, TC; Paulweber, B; Samonigg, H.
Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk.
Breast Cancer Res Treat. 2005; 90(2):113-115 Doi: 10.1007/s10549-004-3607-7
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Führende Autor*innen der Med Uni Graz
Langsenlehner Uwe
Co-Autor*innen der Med Uni Graz
Köppel Herwig
Krippl Peter
Langsenlehner Tanja
Renner Wilfried
Samonigg Hellmut
Wascher Thomas
Yazdani-Biuki Babak

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Interleukin-10 (IL-10) is an immunosuppressive cytokine which may facilitate development of cancer by supporting tumor escape from the immune response. A [TCATA] haplotype formed by polymorphisms at positions -3575, -2763, -1082, -819 and -592 in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the -592C > A polymorphism. Aim of the present study was to analyze the role of the IL-10 [TCATA] haplotype for breast cancer. We performed a case-control study including 500 female patients with histologically confirmed breast cancer and 500 female, age-matched, healthy control subjects from population-based screening studies. The -592C > A polymorphism was determined by a 5'-nuclease assay (TaqMan). Frequency of the homozygous -592 AA genotype, indicating homozygosity for the [TCATA] haplotype, was 4.2% among patients and 7.3% among controls (p=0.038; odds ratio 0.56; 95% confidence interval 0.32-0.97). IL-10 genotypes were not associated with tumor size, histological grading, estrogen or progesterone receptor status and age at diagnosis. Therefore we conclude that the IL-10 -592C > A promoter polymorphism may be associated with a reduced breast cancer risk.
Find related publications in this database (using NLM MeSH Indexing)
- epidemiology
Breast Neoplasms - epidemiology Breast Neoplasms - genetics
Case-Control Studies -
Female -
Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics
Haplotypes - genetics
Humans -
Interleukin-10 - genetics
Matched-Pair Analysis -
Polymorphism, Genetic -
Promoter Regions, Genetic - genetics
Risk -

Find related publications in this database (Keywords)
breast cancer
interleukin-10 polymorphism
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