Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Langsenlehner, U; Krippl, P; Renner, W; Yazdani-Biuki, B; Eder, T; Köppel, H; Wascher, TC; Paulweber, B; Samonigg, H.
Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk.
Breast Cancer Res Treat. 2005; 90(2):113-115
Doi: 10.1007/s10549-004-3607-7
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- Führende Autor*innen der Med Uni Graz
- Langsenlehner Uwe
- Co-Autor*innen der Med Uni Graz
- Köppel Herwig
- Krippl Peter
- Langsenlehner Tanja
- Renner Wilfried
- Samonigg Hellmut
- Wascher Thomas
- Yazdani-Biuki Babak
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- Abstract:
- Interleukin-10 (IL-10) is an immunosuppressive cytokine which may facilitate development of cancer by supporting tumor escape from the immune response. A [TCATA] haplotype formed by polymorphisms at positions -3575, -2763, -1082, -819 and -592 in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the -592C > A polymorphism. Aim of the present study was to analyze the role of the IL-10 [TCATA] haplotype for breast cancer. We performed a case-control study including 500 female patients with histologically confirmed breast cancer and 500 female, age-matched, healthy control subjects from population-based screening studies. The -592C > A polymorphism was determined by a 5'-nuclease assay (TaqMan). Frequency of the homozygous -592 AA genotype, indicating homozygosity for the [TCATA] haplotype, was 4.2% among patients and 7.3% among controls (p=0.038; odds ratio 0.56; 95% confidence interval 0.32-0.97). IL-10 genotypes were not associated with tumor size, histological grading, estrogen or progesterone receptor status and age at diagnosis. Therefore we conclude that the IL-10 -592C > A promoter polymorphism may be associated with a reduced breast cancer risk.
- Find related publications in this database (using NLM MeSH Indexing)
- - epidemiology
- Breast Neoplasms - epidemiology Breast Neoplasms - genetics
- Case-Control Studies -
- Female -
- Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics
- Haplotypes - genetics
- Humans -
- Interleukin-10 - genetics
- Matched-Pair Analysis -
- Polymorphism, Genetic -
- Promoter Regions, Genetic - genetics
- Risk -
- Find related publications in this database (Keywords)
- breast cancer
- epidemiology
- genetics
- interleukin-10 polymorphism