Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gattringer, T; Pinter, D; Enzinger, C; Seifert-Held, T; Kneihsl, M; Fandler, S; Pichler, A; Barro, C; Gröbke, S; Voortman, M; Pirpamer, L; Hofer, E; Ropele, S; Schmidt, R; Kuhle, J; Fazekas, F; Khalil, M.
Serum neurofilament light is sensitive to active cerebral small vessel disease.
Neurology. 2017; 89(20):2108-2114
Doi: 10.1212/WNL.0000000000004645
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- Führende Autor*innen der Med Uni Graz
- Gattringer Thomas
- Pinter Daniela Theresia
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fandler-Höfler Simon
- Fazekas Franz
- Hofer Edith
- Khalil Michael
- Kneihsl Markus
- Pichler Alexander
- Pirpamer Lukas
- Ropele Stefan
- Schmidt Reinhold
- Seifert-Held Thomas
- Voortman Margarete Maria
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- Abstract:
- To explore whether serum neurofilament light chain protein (NfL) levels are increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared to healthy controls and to determine the subsequent course and determinants of NfL levels in a longitudinal manner. In a prospectively collected group of symptomatic patients with an RSSI (n = 79, mean age 61 ± 11 years, 67% male), we analyzed brain MRI and serum NfL using a Single Molecule Array (Simoa) assay at baseline and at 3 and 15 months after stroke. Community-dwelling healthy age- and sex-matched individuals with comparable severity of MRI white matter hyperintensities (WMH) (n = 53) served as controls. Patients with an RSSI had higher NfL baseline levels compared to controls (73.45 vs 34.59 pg/mL, p < 0.0001), and they were increasingly higher with the time from stroke symptom onset to blood sampling (median 4 days, range 1-11 days, rs = 0.51, p < 0.0001). NfL levels remained increased at the 3-month follow-up but returned to normal at 15 months after stroke. NfL levels were associated with RSSI size and baseline WMH severity and were especially high in patients with new, clinically silent cerebral small vessel disease (CSVD)-related lesions at follow-up. Serum NfL is increased in patients with an RSSI and the occurrence of new CSVD-related MRI lesions, even when clinically silent. This suggests NfL as a blood biomarker for active CSVD. © 2017 American Academy of Neurology.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - blood
- Cerebral Small Vessel Diseases - blood
- Cerebral Small Vessel Diseases - diagnostic imaging
- Female -
- Follow-Up Studies -
- Humans -
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Neurofilament Proteins - blood
- Stroke, Lacunar - blood
- Stroke, Lacunar - diagnostic imaging