Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Talaei-Khoei, M; Fischerauer, SF; Jha, R; Ring, D; Chen, N; Vranceanu, AM.
Bidirectional mediation of depression and pain intensity on their associations with upper extremity physical function.
J Behav Med. 2018; 41(3):309-317 Doi: 10.1007/s10865-017-9891-6
Web of Science PubMed FullText FullText_MUG


Co-Autor*innen der Med Uni Graz
Fischerauer Stefan Franz

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Pain intensity and symptoms of depression are correlated and individually associated with decreased physical function. We compared two explanatory mediation models; one with depression as mediator of the association of pain intensity with physical function and the other one with pain intensity as the mediator of the effect of depression on physical function. In a cross-sectional study, 102 patients with upper extremity musculoskeletal illness completed measures of pain intensity, PROMIS depression CAT, PROMIS physical function-upper extremity CAT and demographics. We determined that pain intensity and symptoms of depression were partial mediators of their respective and independent effects on physical function. While depression had a larger standardized mediation effect and a bigger kappa-squared (κ 2) effect size compared to pain intensity, the actual proportion of variance in physical function that could be explained by the mediated effects (i.e., R 2 mediation effect size) was equal in both models suggesting that the two mediation models have equal ability to explain variations in physical function. The bidirectional mediation effect suggests a reinforcement mechanism, in which, pain intensity and symptoms of depression reciprocally influence their negative impacts on physical function among patients with musculoskeletal illness.

Find related publications in this database (Keywords)
Physical function
Upper extremity
Bidirectional mediation
© Med Uni Graz Impressum