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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Talakić, E; Schaffellner, S; Kniepeiss, D; Mueller, H; Stauber, R; Quehenberger, F; Schoellnast, H.
CT perfusion imaging of the liver and the spleen in patients with cirrhosis: Is there a correlation between perfusion and portal venous hypertension?
Eur Radiol. 2017; 27(10):4173-4180 Doi: 10.1007/s00330-017-4788-x [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Schoellnast Helmut
Talakic Emina
Co-Autor*innen der Med Uni Graz
Kniepeiss Daniela
Müller Helmut
Quehenberger Franz
Schaffellner Silvia
Stauber Rudolf

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OBJECTIVES: To correlate hepatic and splenic CT perfusion parameters with hepatic venous pressure gradient (HVPG) measurements in patients with cirrhosis. METHODS: Twenty-one patients with cirrhosis (males, 17; females, 4; mean ± SD age, 57 ± 7 years) underwent hepatic and splenic perfusion CT on a 320-detector row volume scanner as well as invasive measurement of HVPG. Different CT perfusion algorithms (maximum slope analysis and Patlak plot) were used to measure hepatic arterial flow (HAF), portal venous flow (PVF), hepatic perfusion index (HPI), splenic arterial flow (SAF), splenic blood volume (SBV) and splenic clearance (SCL). Hepatic and splenic perfusion parameters were correlated with HVPG, and sensitivity and specificity for detection of severe portal hypertension (≥12 mmHg) were calculated. RESULTS: The Spearman correlation coefficient was -0.53 (p < 0.05) between SAF and HVPG, and -0.68 (p < 0.01) between HVPG and SCL. Using a cut-off value of 125 ml/min/100 ml for SCL, sensitivity for detection of a HVPG of ≥12 mmHg was 94%, and specificity 100%. There was no significant correlation between hepatic perfusion parameters and HVPG. CONCLUSION: CT perfusion in patients with cirrhosis showed a strong correlation between SCL and HVPG and may be used for detection of severe portal hypertension. KEY POINTS: • SAF and SCL are statistically significantly correlated with HVPG • SCL showed stronger correlation with HVPG than SAF • 125 ml/min/100 ml SCL-cut-off yielded 94 % sensitivity, 100 % specificity for severe PH • HAF, PVF and HPI showed no statistically significant correlation with HVPG.
Find related publications in this database (using NLM MeSH Indexing)
Algorithms - administration & dosage
Female - administration & dosage
Hepatic Veins - administration & dosage
Humans - administration & dosage
Hypertension, Portal - diagnostic imaging
Liver - blood supply, diagnostic imaging
Liver Cirrhosis - diagnostic imaging
Male - administration & dosage
Middle Aged - administration & dosage
Perfusion Imaging - administration & dosage
Portal Pressure - administration & dosage
Portal Vein - diagnostic imaging
Sensitivity and Specificity - administration & dosage
Spleen - blood supply, diagnostic imaging
Tomography, X-Ray Computed - administration & dosage

Find related publications in this database (Keywords)
Portal hypertension
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