Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Talakić, E; Schaffellner, S; Kniepeiss, D; Mueller, H; Stauber, R; Quehenberger, F; Schoellnast, H.
CT perfusion imaging of the liver and the spleen in patients with cirrhosis: Is there a correlation between perfusion and portal venous hypertension?
Eur Radiol. 2017; 27(10):4173-4180
Doi: 10.1007/s00330-017-4788-x
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- Führende Autor*innen der Med Uni Graz
- Schoellnast Helmut
- Talakic Emina
- Co-Autor*innen der Med Uni Graz
- Kniepeiss Daniela
- Müller Helmut
- Quehenberger Franz
- Schaffellner Silvia
- Stauber Rudolf
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- Abstract:
- OBJECTIVES: To correlate hepatic and splenic CT perfusion parameters with hepatic venous pressure gradient (HVPG) measurements in patients with cirrhosis. METHODS: Twenty-one patients with cirrhosis (males, 17; females, 4; mean ± SD age, 57 ± 7 years) underwent hepatic and splenic perfusion CT on a 320-detector row volume scanner as well as invasive measurement of HVPG. Different CT perfusion algorithms (maximum slope analysis and Patlak plot) were used to measure hepatic arterial flow (HAF), portal venous flow (PVF), hepatic perfusion index (HPI), splenic arterial flow (SAF), splenic blood volume (SBV) and splenic clearance (SCL). Hepatic and splenic perfusion parameters were correlated with HVPG, and sensitivity and specificity for detection of severe portal hypertension (≥12 mmHg) were calculated. RESULTS: The Spearman correlation coefficient was -0.53 (p < 0.05) between SAF and HVPG, and -0.68 (p < 0.01) between HVPG and SCL. Using a cut-off value of 125 ml/min/100 ml for SCL, sensitivity for detection of a HVPG of ≥12 mmHg was 94%, and specificity 100%. There was no significant correlation between hepatic perfusion parameters and HVPG. CONCLUSION: CT perfusion in patients with cirrhosis showed a strong correlation between SCL and HVPG and may be used for detection of severe portal hypertension. KEY POINTS: • SAF and SCL are statistically significantly correlated with HVPG • SCL showed stronger correlation with HVPG than SAF • 125 ml/min/100 ml SCL-cut-off yielded 94 % sensitivity, 100 % specificity for severe PH • HAF, PVF and HPI showed no statistically significant correlation with HVPG.
- Find related publications in this database (using NLM MeSH Indexing)
- Algorithms - administration & dosage
- Female - administration & dosage
- Hepatic Veins - administration & dosage
- Humans - administration & dosage
- Hypertension, Portal - diagnostic imaging
- Liver - blood supply, diagnostic imaging
- Liver Cirrhosis - diagnostic imaging
- Male - administration & dosage
- Middle Aged - administration & dosage
- Perfusion Imaging - administration & dosage
- Portal Pressure - administration & dosage
- Portal Vein - diagnostic imaging
- Sensitivity and Specificity - administration & dosage
- Spleen - blood supply, diagnostic imaging
- Tomography, X-Ray Computed - administration & dosage
- Find related publications in this database (Keywords)
- CT-perfusion
- Liver
- Spleen
- Cirrhosis
- Portal hypertension