Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stampfer, L; Deutschmann, A; Dür, E; Eitelberger, FG; Fürpass, T; Gorkiewicz, G; Heinz-Erian, P; Heller, I; Herzog, K; Hopfer, B; Kerbl, R; Klug, E; Krause, R; Leitner, E; Mache, C; Müller, T; Pansy, J; Pocivalnik, M; Scheuba, E; Schneditz, G; Schweintzger, G; Sterniczky, E; Zechner, E; Hauer, AC; Högenauer, C; Hoffmann, KM.
Causes of hematochezia and hemorrhagic antibiotic-associated colitis in children and adolescents.
Medicine (Baltimore). 2017; 96(33):e7793-e7793
Doi: 10.1097/MD.0000000000007793
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- Führende Autor*innen der Med Uni Graz
- Hoffmann Karl Martin
- Stampfer Laura
- Co-Autor*innen der Med Uni Graz
- Deutschmann Andrea
- Gorkiewicz Gregor
- Hauer Almuthe
- Herzog Kathrin
- Hoegenauer Christoph
- Krause Robert
- Leitner-Meyer Eva
- Mache Christoph
- Pansy Jasmin
- Ribitsch Mirjam
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- Abstract:
- Diseases causing hematochezia range from benign to potentially life-threatening. Systematic pediatric data on the causes of hematochezia are scarce. We studied the underlying causes and long-term outcome of hematochezia in children. We further investigated the relevance of antibiotic-associated hemorrhagic colitis in children, especially if caused by Klebsiella oxytoca.Infants, children, and adolescents with hematochezia were recruited prospectively. Patients were grouped according to age (<1 year, 1-5 years, 6-13 years, >14 years). In addition to routine diagnostics, K oxytoca stool culture and toxin analysis was performed. We collected data on history, laboratory findings, microbiological diagnostic, imaging, final diagnosis, and long-term outcome.We included 221 patients (female 46%; age 0-19 years). In 98 (44%), hematochezia was caused by infectious diseases. Endoscopy was performed in 30 patients (13.6%). No patient died due to the underlying cause of hematochezia. The most common diagnoses according to age were food protein-induced proctocolitis in infants, bacterial colitis in young children, and inflammatory bowel disease in children and adolescents. Seventeen (7.7%) had a positive stool culture for K oxytoca. Antibiotic-associated colitis was diagnosed in 12 (5%) patients: 2 caused by K oxytoca and 2 by Clostridium difficile; in the remaining 8 patients, no known pathobiont was identified.Infections were the most common cause of hematochezia in this study. In most patients, invasive diagnostic procedures were not necessary. Antibiotic-associated hemorrhagic colitis caused by K oxytoca was an uncommon diagnosis in our cohort. Antibiotic-associated colitis with hematochezia might be caused by pathobionts other than C difficile or K oxytoca.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Anti-Bacterial Agents - adverse effects
- Child -
- Child, Preschool -
- Enterocolitis - complications
- Enterocolitis, Pseudomembranous - etiology
- Enterocolitis, Pseudomembranous - microbiology
- Female -
- Gastrointestinal Hemorrhage - etiology
- Gastrointestinal Hemorrhage - microbiology
- Humans -
- Infant -
- Infant, Newborn -
- Klebsiella Infections - complications
- Klebsiella oxytoca - isolation & purification
- Male -
- Young Adult -
- Find related publications in this database (Keywords)
- antibiotic-associated colitis
- children
- hematochezia
- Klebsiella oxytoca
- proctocolitis