Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Trauner, M; Wagner, M; Fickert, P; Zollner, G.
Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis.
J Clin Gastroenterol. 2005; 39(4 Suppl 2):S111-S124 [OPEN ACCESS]
Web of Science PubMed FullText Google Scholar

 

Autor/innen der Med Uni Graz:
Fickert Peter
Trauner Michael
Wagner Martin
Zollner Gernot
Altmetrics:

Dimensions Citations:

Plum Analytics:
Abstract:
Hepatobiliary transport systems are responsible for hepatic uptake and excretion of bile salts and other biliary constituents (eg, bilirubin) into bile. Hereditary transport defects can result in progressive familial and benign recurrent intrahepatic cholestasis. Exposure to acquired cholestatic injury (eg, drugs, hormones, proinflammatory cytokines, biliary obstruction or destruction) also results in altered expression and function of hepatic uptake and excretory systems, changes that may maintain and contribute to cholestasis and jaundice. Recruitment of alternative efflux pumps and induction of phase I and II detoxifying enzymes may limit hepatic accumulation of potentially toxic biliary constituents in cholestasis by providing alternative metabolic and escape routes. These molecular changes are mediated by bile salts, proinflammatory cytokines, drugs, and hormones at a transcriptional and posttranscriptional level. Alterations of hepatobiliary transporters and enzymes are not only relevant for a better understanding of the pathophysiology of cholestatic liver diseases, but may also represent important targets for pharmacotherapy. Drugs (eg, ursodeoxycholic acid, rifampicin) used to treat cholestatic liver diseases and pruritus may counteract cholestasis via stimulation of defective transporter expression and function. In addition, therapeutic strategies may be aimed at supporting and stimulating alternative detoxification pathways and elimination routes for bile salts in cholestasis.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Bile -
Bile Acids and Salts - metabolism
Biliary Tract - metabolism
Biological Transport, Active -
Cholangitis, Sclerosing - metabolism
Cholestasis - metabolism Cholestasis - therapy
Cholestasis, Intrahepatic - metabolism
Humans -
Liver - metabolism
Liver Cirrhosis, Biliary - metabolism
Mice -
Mutation -
Receptors, Cytoplasmic and Nuclear - drug effects
Ursodeoxycholic Acid - therapeutic use

Find related publications in this database (Keywords)
cholestasis
jaundice
cytochrome P450 enzymes
nuclear (orphan) receptors
ATP-binding cassette transporter
© Meduni Graz Impressum