Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Platzer, M; Dalkner, N; Fellendorf, FT; Birner, A; Bengesser, SA; Queissner, R; Kainzbauer, N; Pilz, R; Herzog-Eberhard, S; Hamm, C; Hörmanseder, C; Maget, A; Rauch, P; Mangge, H; Fuchs, D; Zelzer, S; Schütze, G; Moll, N; Schwarz, MJ; Mansur, RB; McIntyre, RS; Reininghaus, EZ.
Tryptophan breakdown and cognition in bipolar disorder.
Psychoneuroendocrinology. 2017; 81(3):144-150
Doi: 10.1016/j.psyneuen.2017.04.015
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Dalkner Nina
- Platzer Martina
- Co-Autor*innen der Med Uni Graz
- Bengesser Susanne
- Birner Armin
- Fellendorf Frederike
- Hamm Carlo
- Herzog-Eberhard Simone
- Kainzbauer Nora
- Maget Alexander
- Mangge Harald
- Pilz Rene
- Queissner Robert
- Reininghaus Eva
- Zelzer Sieglinde
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- Abstract:
- It has been demonstrated that bipolar disorder (BD) is often accompanied by cognitive deficits across all subdomains including verbal memory, attention and executive functioning. Cognitive deficits are observed both during episodes of mania or depression, as well as during the euthymic phase. It has been proposed that chronic immune-mediated inflammation in the central nervous system results in alterations in neural structures that subserve cognitive function. Kynurenine is an intermediate in the inflammatory cascade and can be peripherally measured to proxy inflammatory activity. Herein, we sought to determine whether serum levels of kynurenine and/or its metabolites were associated with cognitive function in BD. In this investigation 68 euthymic individuals with BD according to DSM-IV completed a cognitive test battery to asses premorbid intelligence (Multiple Choice Word Test; MWT-B), verbal memory (California Verbal Learning Test; CVLT), attention (d2 Test of Attention; d2 test, Trail Making Test-A; TMT-A, Stroop word reading/Stroop color naming) and executive functioning (TMT-B, Stroop interference). In addition, fasting blood samples were taken and serum levels of kynurenine and its metabolites 3-hydroxykynurenine and kynurenic acid were analyzed. Subsequently ratios were formed from individual parameters. Patient data were compared with those of a mentally healthy control group (n=93). In male participants with BD only we found a significant negative correlation between the 3-hydroxykynurenine to kynurenic acid ratio and performance on the CVLT. Additionally, the kynurenine to 3-hydroxykynurenine ratio was associated with performance on a sub-score of the CVLT. Those associations were neither present in female individuals with BD nor in the control group. Our findings suggest that a shift towards the hydroxykynurenine arm of the kynurenine pathway may be associated with poorer memory performance due to its effects on neuronal functioning and neurogenesis in the hippocampus. Our results implicate a mechanistic role of central inflammatory processes in cognitive functions in adults with bipolar disorder. Copyright © 2017 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bipolar Disorder - blood
- Bipolar Disorder - metabolism
- Bipolar Disorder - psychology
- Case-Control Studies -
- Cognition -
- Female -
- Humans -
- Kynurenic Acid - blood
- Kynurenine - analogs & derivatives
- Kynurenine - blood
- Male -
- Middle Aged -
- Neuropsychological Tests -
- Sex Factors -
- Tryptophan - metabolism
- Find related publications in this database (Keywords)
- Bipolar disorder
- Cognition
- Neuroprogression
- Tryptophan-kynurenine-pathway