Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Prattes, J; Hoenigl, M; Krause, R; Buzina, W; Valentin, T; Reischies, F; Koidl, C; Zollner-Schwetz, I.
Invasive aspergillosis in patients with underlying liver cirrhosis: a prospective cohort study.
Med Mycol. 2017; 55(8):803-812
Doi: 10.1093/mmy/myx011
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- Führende Autor*innen der Med Uni Graz
- Prattes Jürgen
- Co-Autor*innen der Med Uni Graz
- Buzina Walter
- Hönigl Martin
- Koidl Christoph
- Krause Robert
- Reischies-Meikl Frederike Marie Josefine
- Valentin Thomas
- Zollner-Schwetz Ines
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- Abstract:
- The aim of this study was to determine the prevalence of invasive aspergillosis (IA) in patients with liver cirrhosis and the performance of serum galactomannan (GM) screening. Patients with decompensated liver cirrhosis and patients with compensated liver cirrhosis presenting with fever and/or respiratory symptoms were prospectively enrolled. All patients were screened by serum GM twice weekly irrespective of clinical signs and symptoms. Positive serum GM triggered work-up consisting of chest computed tomography and in case of pathological findings bronchoscopy. 150 patients were included in the study. Two (1.3%) had probable, one (0.7%) had possible, and 147 (98%) had no evidence of IA. Both patients with probable IA had compensated liver cirrhosis. Sensitivity for serum GM screening for probable versus no IA was 0.5 (95% CI, 0.09-0.91), specificity 0.97 (95% CI: 0.92-0.99), negative predictive value 0.99 (95% CI, 0.96-0.99) and positive predictive value (PPV) 0.17 (95% CI, 0.01-0.64). PPV was 0.5 (95% CI, 0.03-0.98) in patients with clinical suspicion of IA. In conclusion, prevalence of IA in patients with liver cirrhosis seems to be low. Targeted GM testing in case of clinical suspicion of IA may be associated with markedly higher PPVs when compared to universal GM screening in patients with liver cirrhosis. © The Author 2017. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aspergillosis - blood
- Aspergillosis - complications
- Aspergillosis - diagnosis
- Aspergillosis - mortality
- Cohort Studies -
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Liver Cirrhosis - blood
- Liver Cirrhosis - complications
- Male -
- Mannans - blood
- Middle Aged -
- Prevalence -
- Prospective Studies -
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- liver cirrhosis
- aspergillosis
- galactomannan
- prevalence
- voriconazole