Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stanta, G; Jahn, SW; Bonin, S; Hoefler, G.
Tumour heterogeneity: principles and practical consequences.
Virchows Arch. 2016; 469(4):371-384
Doi: 10.1007/s00428-016-1987-9
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Höfler Gerald
- Jahn Stephan
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- Abstract:
- Two major reasons compel us to study tumour heterogeneity: firstly, it represents the basis of acquired therapy resistance, and secondly, it may be one of the major sources of the low level of reproducibility in clinical cancer research. The present review focuses on the heterogeneity of neoplastic disease, both within the primary tumour and between primary tumour and metastases. We discuss different levels of heterogeneity and the current understanding of the phenomenon, as well as imminent developments relevant for clinical research and diagnostic pathology. It is necessary to develop new tools to study heterogeneity and new biomarkers for heterogeneity. Established and new in situ methods will be very useful. In future studies, not only clonal heterogeneity needs to be addressed but also non-clonal phenotypic heterogeneity which might be important for therapy resistance. We also review heterogeneity established in major tumour types, in order to explore potential similarities that might help to define new strategies for targeted therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Plasticity - physiology
- Genetic Heterogeneity -
- Humans -
- Neoplasm Metastasis - diagnosis
- Neoplasm Metastasis - pathology
- Neoplasms - diagnosis
- Neoplasms - metabolism
- Neoplasms - therapy
- Phenotype -
- Reproducibility of Results -
- Find related publications in this database (Keywords)
- Tumour heterogeneity
- Phenotypic
- Clonal
- Epigenetic
- Molecular
- Functional plasticity
- Intratumour
- Intertumour
- Spatial
- Temporal