Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fahrleitner-Pammer, A; Wagner, D; Krisper, P; Amrein, K; Dimai, H.
Teriparatide treatment in a heart transplant patient with a chronic kidney disease and a low-turnover bone disease: a case report.
Osteoporos Int. 2017; 28(3):1149-1152
Doi: 10.1007/s00198-016-3858-2
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Fahrleitner-Pammer Astrid
- Co-Autor*innen der Med Uni Graz
- Amrein Karin
- Dimai Hans Peter
- Krisper Peter
- Wagner Doris
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- Abstract:
- Low-turnover bone disease is a complication of chronic kidney disease and a long-term steroid therapy. Currently, the only bone anabolic treatment available is teriparatide (TPTD). So far, no data exist in heart transplant patients, and only one single case with histomorphometric analysis of a dialysis patient with a low-turnover bone disease has been published. The current report shows the effect of a 1-year TPTD therapy in a cardiac transplant patient with 10 vertebral and 3 peripheral fractures who had developed a chronic kidney failure while receiving triple immunosuppressive therapy. A transiliac bone biopsy following tetracycline labeling was performed prior and after 1 year of treatment, showing an increase in the bone formation and improvement of the structural indices (20-fold increase of osteoid volume/bone volume, fourfold increase of osteoid surface/bone surface and increases of wall thickness (+15%), trabecular thickness (+9%), and trabecular number (+38%)). Bone mineral density was stable, no new vertebral fractures had occurred, the therapy was well-tolerated, and the patient improved clinically.
- Find related publications in this database (using NLM MeSH Indexing)
- Bone Density - drug effects
- Bone Density Conservation Agents - therapeutic use
- Bone Remodeling - drug effects
- Glucocorticoids - adverse effects
- Heart Transplantation - adverse effects
- Humans -
- Immunosuppressive Agents - adverse effects
- Kidney Failure, Chronic - complications
- Male -
- Middle Aged -
- Osteoporosis - drug therapy
- Osteoporosis - etiology
- Osteoporosis - physiopathology
- Osteoporotic Fractures - etiology
- Osteoporotic Fractures - physiopathology
- Osteoporotic Fractures - prevention & control
- Teriparatide - therapeutic use
- Find related publications in this database (Keywords)
- Bone biopsy
- Cardiac transplantation
- Histomorphometrie
- Low-turn over bone disease in CKD-MBD
- Teriparatide