Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fahrleitner-Pammer, A; Wagner, D; Krisper, P; Amrein, K; Dimai, H.
Teriparatide treatment in a heart transplant patient with a chronic kidney disease and a low-turnover bone disease: a case report.
Osteoporos Int. 2017; 28(3):1149-1152 Doi: 10.1007/s00198-016-3858-2 (- Case Report) [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Fahrleitner-Pammer Astrid
Co-Autor*innen der Med Uni Graz
Amrein Karin
Dimai Hans Peter
Krisper Peter
Wagner Doris

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Low-turnover bone disease is a complication of chronic kidney disease and a long-term steroid therapy. Currently, the only bone anabolic treatment available is teriparatide (TPTD). So far, no data exist in heart transplant patients, and only one single case with histomorphometric analysis of a dialysis patient with a low-turnover bone disease has been published. The current report shows the effect of a 1-year TPTD therapy in a cardiac transplant patient with 10 vertebral and 3 peripheral fractures who had developed a chronic kidney failure while receiving triple immunosuppressive therapy. A transiliac bone biopsy following tetracycline labeling was performed prior and after 1 year of treatment, showing an increase in the bone formation and improvement of the structural indices (20-fold increase of osteoid volume/bone volume, fourfold increase of osteoid surface/bone surface and increases of wall thickness (+15%), trabecular thickness (+9%), and trabecular number (+38%)). Bone mineral density was stable, no new vertebral fractures had occurred, the therapy was well-tolerated, and the patient improved clinically.
Find related publications in this database (using NLM MeSH Indexing)
Bone Density - drug effects
Bone Density Conservation Agents - therapeutic use
Bone Remodeling - drug effects
Glucocorticoids - adverse effects
Heart Transplantation - adverse effects
Humans -
Immunosuppressive Agents - adverse effects
Kidney Failure, Chronic - complications
Male -
Middle Aged -
Osteoporosis - drug therapy
Osteoporosis - etiology
Osteoporosis - physiopathology
Osteoporotic Fractures - etiology
Osteoporotic Fractures - physiopathology
Osteoporotic Fractures - prevention & control
Teriparatide - therapeutic use

Find related publications in this database (Keywords)
Bone biopsy
Cardiac transplantation
Low-turn over bone disease in CKD-MBD
© Med Uni Graz Impressum