Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ulbing, M; Kirsch, AH; Leber, B; Lemesch, S; Münzker, J; Schweighofer, N; Hofer, D; Trummer, O; Rosenkranz, AR; Müller, H; Eller, K; Stadlbauer, V; Obermayer-Pietsch, B.
MicroRNAs 223-3p and 93-5p in patients with chronic kidney disease before and after renal transplantation.
Bone. 2017; 95(4):115-123
Doi: 10.1016/j.bone.2016.11.016
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- Führende Autor*innen der Med Uni Graz
- Stadlbauer-Köllner Vanessa
- Ulbing Matthias
- Co-Autor*innen der Med Uni Graz
- Eller Kathrin
- Kirsch Alexander
- Leber Bettina
- Müller Helmut
- Münzker Julia
- Obermayer-Pietsch Barbara
- Rosenkranz Alexander
- Schweighofer Natascha
- Sudy Daniela
- Trummer Olivia
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- Abstract:
- Chronic kidney disease (CKD) is associated with a multifactorial dysregulation of bone and vascular calcification and closely linked to increased cardiovascular mortality and concomitant bone disease. We aimed to investigate specific microRNA (miRNA) signatures in CKD patients to find indicators for vascular calcification and/or bone mineralization changes during CKD and after kidney transplantation (KT). A miRNA array was used to investigate serum miRNA profiles in CKD patients, then selected miRNAs were quantified in a validation cohort comprising 73 patients in CKD stages 3 to 5, 67 CKD patients after KT, and 36 healthy controls. A spectrum of biochemical parameters including markers for kidney function, inflammation, glucose, and mineral metabolism was determined. The relative expression of miR-223-3p and miR-93-5p was down-regulated in patients with CKD stage 4 and 5 compared to healthy controls. This down-regulation disappeared after kidney transplantation even when lower glomerular filtration rates (eGFR) persisted. MiR-223-3p and miR-93-5p were associated with interleukin-6 (IL-6) and eGFR levels, and by trend with interleukin-8 (IL-8), C-peptide, hematocrit, and parathyroid hormone (PTH). This study contributes new knowledge of serum miRNA expression profiles in CKD, potentially reflecting pathophysiological changes of bone and calcification pathways associated with inflammation, vascular calcification, mineral and glucose metabolism. Identified miRNA signatures can contribute to future risk markers or future therapeutic targets in bone and kidney disease. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Bone and Bones - metabolism
- Case-Control Studies -
- Disease Progression -
- Down-Regulation - genetics
- Female -
- Glomerular Filtration Rate -
- Humans -
- Kidney Transplantation -
- Male -
- MicroRNAs - genetics
- MicroRNAs - metabolism
- Middle Aged -
- Regression Analysis -
- Renal Insufficiency, Chronic - blood
- Renal Insufficiency, Chronic - genetics
- Renal Insufficiency, Chronic - physiopathology
- Renal Insufficiency, Chronic - therapy
- Find related publications in this database (Keywords)
- MicroRNA
- Chronic kidney disease
- Bone metabolism
- Kidney transplantation
- Biomarker
- CKD-MBD