Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stotz, M; Liegl-Atzwanger, B; Posch, F; Mrsic, E; Thalhammer, M; Stojakovic, T; Bezan, A; Pichler, M; Gerger, A; Szkandera, J.
Blood-Based Biomarkers Are Associated with Disease Recurrence and Survival in Gastrointestinal Stroma Tumor Patients after Surgical Resection.
PLoS One. 2016; 11(7):e0159448-e0159448
Doi: 10.1371/journal.pone.0159448
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- Führende Autor*innen der Med Uni Graz
- Liegl-Atzwanger Bernadette
- Stotz Michael
- Co-Autor*innen der Med Uni Graz
- Gerger Armin
- Pichler Martin
- Posch Florian
- Stojakovic Tatjana
- Szkandera Joanna
- Terbuch Angelika
- Thalhammer Michael
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- Abstract:
- Inflammatory blood count biomarkers may improve recurrence risk stratification and inform long-term prognosis of cancer patients. Here, we quantify the prognostic impact of blood-based biomarkers on recurrence risk and long-term survival in a large cohort of gastrointestinal stroma tumor (GIST) patients after curative surgery. One-hundred-forty-nine consecutive GIST patients were followed-up for a median period of 4.8 years. Local recurrence, distant metastasis, and death occurred in 9, 21, and 31 patients, respectively. Time-to-event and competing risk analysis were applied to study the association between haemoglobin (Hb) level, white blood cell count (WBC), neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte/monocyte ratio (LMR), and platelet/lymphocyte ratio (PLR) with risk of local or distant recurrence (RR), recurrence free survival (RFS), and overall survival (OS). A low Hb (p = 0.029), and elevations in the parameters WBC (p = 0.004), NLR (p = 0.015) and dNLR (p = 0.037) were associated with a poor OS in GIST patients in multivariate analysis. Moreover, a low Hb (p = 0.049) and an elevated WBC (p = 0.001), NLR (p = 0.007), dNLR (p = 0.043) and PLR (p = 0.024) were independently associated with decreased RFS after adjusting for Miettinen score. However, only an increase of dNLR/NLR showed a significant association to higher RR (p = 0.048). Inclusion of NLR or PLR to Miettinen risk score did not reasonably improve the clinical risk prediction of 2-year RFS. Low Hb, elevated WBC, elevated dNLR, and elevated PLR are independent prognostic factors for a worse clinical outcome in GIST patients after curative resection.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers -
- Cause of Death -
- Female -
- Follow-Up Studies -
- Gastrointestinal Stromal Tumors - blood
- Gastrointestinal Stromal Tumors - diagnosis
- Gastrointestinal Stromal Tumors - mortality
- Gastrointestinal Stromal Tumors - surgery
- Humans -
- Leukocyte Count -
- Lymphocyte Count -
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local -
- Neutrophils -
- Postoperative Period -
- Prognosis -
- Retrospective Studies -
- Young Adult -