Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Stotz, M; Liegl-Atzwanger, B; Posch, F; Mrsic, E; Thalhammer, M; Stojakovic, T; Bezan, A; Pichler, M; Gerger, A; Szkandera, J.
Blood-Based Biomarkers Are Associated with Disease Recurrence and Survival in Gastrointestinal Stroma Tumor Patients after Surgical Resection.
PLoS One. 2016; 11(7):e0159448-e0159448 Doi: 10.1371/journal.pone.0159448 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Liegl-Atzwanger Bernadette
Stotz Michael
Co-Autor*innen der Med Uni Graz
Gerger Armin
Pichler Martin
Posch Florian
Stojakovic Tatjana
Szkandera Joanna
Terbuch Angelika
Thalhammer Michael

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Inflammatory blood count biomarkers may improve recurrence risk stratification and inform long-term prognosis of cancer patients. Here, we quantify the prognostic impact of blood-based biomarkers on recurrence risk and long-term survival in a large cohort of gastrointestinal stroma tumor (GIST) patients after curative surgery. One-hundred-forty-nine consecutive GIST patients were followed-up for a median period of 4.8 years. Local recurrence, distant metastasis, and death occurred in 9, 21, and 31 patients, respectively. Time-to-event and competing risk analysis were applied to study the association between haemoglobin (Hb) level, white blood cell count (WBC), neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte/monocyte ratio (LMR), and platelet/lymphocyte ratio (PLR) with risk of local or distant recurrence (RR), recurrence free survival (RFS), and overall survival (OS). A low Hb (p = 0.029), and elevations in the parameters WBC (p = 0.004), NLR (p = 0.015) and dNLR (p = 0.037) were associated with a poor OS in GIST patients in multivariate analysis. Moreover, a low Hb (p = 0.049) and an elevated WBC (p = 0.001), NLR (p = 0.007), dNLR (p = 0.043) and PLR (p = 0.024) were independently associated with decreased RFS after adjusting for Miettinen score. However, only an increase of dNLR/NLR showed a significant association to higher RR (p = 0.048). Inclusion of NLR or PLR to Miettinen risk score did not reasonably improve the clinical risk prediction of 2-year RFS. Low Hb, elevated WBC, elevated dNLR, and elevated PLR are independent prognostic factors for a worse clinical outcome in GIST patients after curative resection.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Biomarkers -
Cause of Death -
Female -
Follow-Up Studies -
Gastrointestinal Stromal Tumors - blood
Gastrointestinal Stromal Tumors - diagnosis
Gastrointestinal Stromal Tumors - mortality
Gastrointestinal Stromal Tumors - surgery
Humans -
Leukocyte Count -
Lymphocyte Count -
Male -
Middle Aged -
Neoplasm Recurrence, Local -
Neutrophils -
Postoperative Period -
Prognosis -
Retrospective Studies -
Young Adult -

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