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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Amerstorfer, F; Fischerauer, SF; Fischer, L; Eichler, J; Draxler, J; Zitek, A; Meischel, M; Martinelli, E; Kraus, T; Hann, S; Stanzl-Tschegg, SE; Uggowitzer, PJ; Löffler, JF; Weinberg, AM; Prohaska, T.
Long-term in vivo degradation behavior and near-implant distribution of resorbed elements for magnesium alloys WZ21 and ZX50.
Acta Biomater. 2016; 42(9 Pt A):440-450 Doi: 10.1016/j.actbio.2016.06.025 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Amerstorfer Florian Ludwig
Weinberg Annelie-Martina
Co-Autor*innen der Med Uni Graz
Eichler Johannes
Fischerauer Stefan Franz
Kraus Tanja
Martinelli Elisabeth

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We report on the long-term effects of degrading magnesium implants on bone tissue in a growing rat skeleton using continuous in vivo micro-Computed Tomography, histological staining and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Two different magnesium alloys-one rapidly degrading (ZX50) and one slowly degrading (WZ21)-were used to evaluate the bone response and distribution of released Mg and Y ions in the femur of male Sprague-Dawley rats. Regardless of whether the alloy degrades rapidly or slowly, we found that bone recovers restitutio ad integrum after complete degradation of the magnesium implant. The degradation of the Mg alloys generates a significant increase in Mg concentration in the cortical bone near the remaining implant parts, but the Mg accumulation disappears after the implant degrades completely. The degradation of the Y-containing alloy WZ21 leads to Y enrichment in adjacent bone tissues and in newly formed bone inside the medullary space. Locally high Y concentrations suggest migration not only of Y ions but also of Y-containing intermetallic particles. However, after the full degradation of the implant the Y-enrichment disappears almost completely. Hydrogen gas formation and ion release during implant degradation did not harm bone regeneration in our samples. Magnesium is generally considered to be one of the most attractive base materials for biodegradable implants, and many magnesium alloys have been optimized to adjust implant degradation. Delayed degradation, however, generates prolonged presence in the organism with the risk of foreign body reactions. While most studies so far have only ranged from several weeks up to 12months, the present study provides data for complete implant degradation and bone regeneration until 24months, for two magnesium alloys (ZX50, WZ21) with different degradation characteristics. μCT monitoring, histological staining and LA-ICP-MS illustrate the distribution of the elements in the neighboring bony tissues during implant degradation, and reveal in particular high concentrations of the rare-earth element Yttrium. Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Alloys - chemistry
Animals -
Calcium - analysis
Implants, Experimental -
Magnesium - chemistry
Male -
Mass Spectrometry -
Phosphorus - analysis
Rats, Sprague-Dawley -
X-Ray Microtomography -
Yttrium - analysis

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