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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Bengesser, SA; Fuchs, R; Lackner, N; Birner, A; Reininghaus, B; Meier-Allard, N; Stracke, A; Kapfhammer, HP; Reininghaus, EZ; Wallner-Liebmann, S.
Endoplasmic Reticulum Stress and Bipolar Disorder - Almost Forgotten Therapeutic Drug Targets in the Unfolded Protein Response Pathway Revisited.
CNS Neurol Disord Drug Targets. 2016; 15(4):403-413 Doi: 10.2174/1871527315666160321104613
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Führende Autor*innen der Med Uni Graz
Bengesser Susanne
Fuchs Robert
Reininghaus Eva
Co-Autor*innen der Med Uni Graz
Birner Armin
Dalkner Nina
Holasek Sandra Johanna
Kapfhammer Hans-Peter
Meier-Allard Nathalie
Reininghaus Bernd
Stracke Anika

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Bipolar Disorder (BD) is characterized by recurring mood swings, which are not completely understood yet. So far, it is an accepted theory that multiple factors contribute to pathogenesis of BD according to the vulnerability-stressmodel. This model combines on the one hand biological predisposing vulnerability, and on the other hand several chronic and acute stressful negative events as underlying mechanisms of BD. Recently, ER (Endoplasmic Reticulum) stress reached the spotlight of BD research again. The expression of the chaperone BiP (syn. GRP78/glucose-regulated protein, 78kDa), which is highly expressed in the Endoplasmic Reticulum (ER), is upregulated by different kinds of mood stabilizers. These results implied that the ER, an organelle which is prone towards different kinds of cellular stress, might be involved in the pathophysiology of BD. This hypothesis was further strengthened by hypothesis driven genetic association studies, which showed significant association of BiP promotor polymorphisms with BD. Also other ER-stress associated genes like XBP1 (X-box binding protein 1) or GRP94 (glucose-regulated protein, 94kDa, synonym for heat shock protein HSP90B1) were recently linked to BD in hypothesis driven gene association studies. In addition to the proteins mentioned before, our review focuses on further UPR (Unfolded Protein Response) related proteins associated with BD and raises the hypothesis that ER-stress may represent a common interface between BD and obesity which is overrepresented in BD patients. Finally, members of the UPR pathway are discussed as putative targets for mood stabilizers.
Find related publications in this database (using NLM MeSH Indexing)
Antimanic Agents - pharmacology
Antimanic Agents - therapeutic use
Bipolar Disorder - drug therapy
Bipolar Disorder - physiopathology
Endoplasmic Reticulum Stress - drug effects
Endoplasmic Reticulum Stress - physiology
Humans -
Protein Unfolding - drug effects
Signal Transduction - drug effects

Find related publications in this database (Keywords)
Bipolar disorder
endoplasmic reticulum
endoplasmic reticulum stress
unfolded protein response
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