Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pasterk, L; Lemesch, S; Leber, B; Trieb, M; Curcic, S; Stadlbauer, V; Schuligoi, R; Schicho, R; Heinemann, A; Marsche, G.
Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression.
Sci Rep. 2016; 6(3):22104-22104
Doi: 10.1038/srep22104
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- Führende Autor*innen der Med Uni Graz
- Marsche Gunther
- Pasterk Lisa
- Co-Autor*innen der Med Uni Graz
- Curcic Sanja
- Heinemann Akos
- Leber Bettina
- Lemesch Sandra
- Schicho Rudolf
- Schuligoi Rufina
- Stadlbauer-Köllner Vanessa
- Trieb Markus
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- Abstract:
- Plasma advanced oxidation protein products (AOPPs), a class of pro-inflammatory pathogenic mediators, accumulate in subjects with chronic kidney disease. Whether AOPPs contribute to coagulation abnormalities, which are frequently seen in uremic patients, is unknown. Here we report that AOPPs activate platelets via a CD36-mediated signaling pathway. Activation of signaling pathways by AOPP-platelet interaction resulted in the expression of several platelet activation markers and rapidly induced the expression of CD40 ligand, triggering platelet adhesion to endothelial cells and promoting endothelial tissue factor expression. AOPPs and serum tissue factor levels were considerably increased in end stage renal disease patients on hemodialysis and a significant correlation of AOPPs and serum tissue factor was found. Interestingly, serum levels of AOPPs and tissue factor were substantially lower in stable kidney transplant patients when compared with hemodialysis patients. Given that CD36 is known to transduce the effects of oxidized lipids into platelet hyperactivity, our findings reveal previously unknown pro-thrombotic activities of oxidized plasma albumin via a CD36 dependent pathway.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Advanced Oxidation Protein Products - blood
- Advanced Oxidation Protein Products - chemistry
- Advanced Oxidation Protein Products - pharmacology
- Aged -
- Aged, 80 and over -
- Blood Platelets - metabolism
- Blood Platelets - pathology
- CD36 Antigens - blood
- CD36 Antigens - genetics
- CD40 Ligand - blood
- CD40 Ligand - genetics
- Endothelial Cells - metabolism
- Endothelial Cells - pathology
- Female -
- Gene Expression Regulation -
- Humans -
- Kidney Failure, Chronic - blood
- Kidney Failure, Chronic - genetics
- Kidney Failure, Chronic - pathology
- Kidney Transplantation -
- Male -
- Middle Aged -
- Platelet Activation - drug effects
- Platelet Aggregation - drug effects
- Renal Dialysis -
- Serum Albumin - chemistry
- Serum Albumin - metabolism
- Serum Albumin - pharmacology
- Signal Transduction -
- Thromboplastin - genetics
- Thromboplastin - metabolism