Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pasterk, L; Lemesch, S; Leber, B; Trieb, M; Curcic, S; Stadlbauer, V; Schuligoi, R; Schicho, R; Heinemann, A; Marsche, G.
Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression.
Sci Rep. 2016; 6(3):22104-22104 Doi: 10.1038/srep22104 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Marsche Gunther
Pasterk Lisa
Co-Autor*innen der Med Uni Graz
Curcic Sanja
Heinemann Akos
Leber Bettina
Lemesch Sandra
Schicho Rudolf
Schuligoi Rufina
Stadlbauer-Köllner Vanessa
Trieb Markus

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Scite (citation analytics):

Plasma advanced oxidation protein products (AOPPs), a class of pro-inflammatory pathogenic mediators, accumulate in subjects with chronic kidney disease. Whether AOPPs contribute to coagulation abnormalities, which are frequently seen in uremic patients, is unknown. Here we report that AOPPs activate platelets via a CD36-mediated signaling pathway. Activation of signaling pathways by AOPP-platelet interaction resulted in the expression of several platelet activation markers and rapidly induced the expression of CD40 ligand, triggering platelet adhesion to endothelial cells and promoting endothelial tissue factor expression. AOPPs and serum tissue factor levels were considerably increased in end stage renal disease patients on hemodialysis and a significant correlation of AOPPs and serum tissue factor was found. Interestingly, serum levels of AOPPs and tissue factor were substantially lower in stable kidney transplant patients when compared with hemodialysis patients. Given that CD36 is known to transduce the effects of oxidized lipids into platelet hyperactivity, our findings reveal previously unknown pro-thrombotic activities of oxidized plasma albumin via a CD36 dependent pathway.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Advanced Oxidation Protein Products - blood
Advanced Oxidation Protein Products - chemistry
Advanced Oxidation Protein Products - pharmacology
Aged -
Aged, 80 and over -
Blood Platelets - metabolism
Blood Platelets - pathology
CD36 Antigens - blood
CD36 Antigens - genetics
CD40 Ligand - blood
CD40 Ligand - genetics
Endothelial Cells - metabolism
Endothelial Cells - pathology
Female -
Gene Expression Regulation -
Humans -
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - genetics
Kidney Failure, Chronic - pathology
Kidney Transplantation -
Male -
Middle Aged -
Platelet Activation - drug effects
Platelet Aggregation - drug effects
Renal Dialysis -
Serum Albumin - chemistry
Serum Albumin - metabolism
Serum Albumin - pharmacology
Signal Transduction -
Thromboplastin - genetics
Thromboplastin - metabolism

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