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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Lamprecht, M; Bogner, S; Steinbauer, K; Schuetz, B; Greilberger, JF; Leber, B; Wagner, B; Zinser, E; Petek, T; Wallner-Liebmann, S; Oberwinkler, T; Bachl, N; Schippinger, G.
Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects.
J Int Soc Sports Nutr. 2015; 12(2):40-40 Doi: 10.1186/s12970-015-0101-z [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Greilberger Joachim
Holasek Sandra Johanna
Leber Bettina

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Zeolites are crystalline compounds with microporous structures of Si-tetrahedrons. In the gut, these silicates could act as adsorbents, ion-exchangers, catalysts, detergents or anti-diarrheic agents. This study evaluated whether zeolite supplementation affects biomarkers of intestinal wall permeability and parameters of oxidation and inflammation in aerobically trained individuals, and whether it could improve their performance. In a randomized, double-blinded, placebo controlled trial, 52 endurance trained men and women, similar in body fat, non-smokers, 20-50 years, received 1.85 g of zeolite per day for 12 weeks. Stool samples for determination of intestinal wall integrity biomarkers were collected. From blood, markers of redox biology, inflammation, and DNA damage were determined at the beginning and the end of the study. In addition, VO2max and maximum performance were evaluated at baseline and after 12 weeks of treatment. For statistical analyses a 2-factor ANOVA was used. At baseline both groups showed slightly increased stool zonulin concentrations above normal. After 12 weeks with zeolite zonulin was significantly (p < 0.05) decreased in the supplemented group. IL-10 increased tendentially (p < 0.1) in the zeolite group. There were no significant changes observed in the other measured parameters. Twelve weeks of zeolite supplementation exerted beneficial effects on intestinal wall integrity as indicated via decreased concentrations of the tight junction modulator zonulin. This was accompanied by mild anti-inflammatory effects in this cohort of aerobically trained subjects. Further research is needed to explore mechanistic explanations for the observations in this study.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Biomarkers - blood
Cholera Toxin - metabolism
DNA Damage -
Dietary Supplements -
Double-Blind Method -
Feces - chemistry
Female -
Humans -
Inflammation - blood
Interleukin-10 - blood
Interleukin-6 - blood
Interleukin-8 - blood
Interleukins - blood
Intestines - drug effects
Male -
Middle Aged -
Nutrition Assessment -
Oxygen Consumption -
Permeability -
Tight Junctions - drug effects
Tumor Necrosis Factor-alpha - blood
Zeolites - pharmacology

Find related publications in this database (Keywords)
Zeolite supplementation
Trained subjects
Leaky gut
Tight junctions
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