Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Schwaberger, B; Pichler, G; Avian, A; Binder-Heschl, C; Baik, N; Urlesberger, B.
Do Sustained Lung Inflations during Neonatal Resuscitation Affect Cerebral Blood Volume in Preterm Infants? A Randomized Controlled Pilot Study.
PLoS One. 2015; 10(9):e0138964-e0138964 Doi: 10.1371/journal.pone.0138964 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Schwaberger Bernhard Christian
Urlesberger Berndt
Co-Autor*innen der Med Uni Graz
Avian Alexander
Baik-Schneditz Nariae
Binder-Heschl Corinna
Pichler Gerhard

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Sustained lung inflations (SLI) during neonatal resuscitation may promote alveolar recruitment in preterm infants. While most of the studies focus on respiratory outcome, the impact of SLI on the brain hasn't been investigated yet. Do SLI affect cerebral blood volume (CBV) in preterm infants? Preterm infants of gestation 28 weeks 0 days to 33 weeks 6 days with requirement for respiratory support (RS) were included in this randomized controlled pilot trial. Within the first 15 minutes after birth near-infrared spectroscopy (NIRS) measurements using 'NIRO-200-NX' (Hamamatsu, Japan) were performed to evaluate changes in CBV and cerebral tissue oxygenation. Two groups were compared based on RS: In SLI group RS was given by applying 1-3 SLI (30 cmH2O for 15 s) continued by respiratory standard care. Control group received respiratory standard care only. 40 infants (20 in each group) with mean gestational age of 32 weeks one day (±2 days) and birth weight of 1707 (±470) g were included. In the control group ΔCBV was significantly decreasing, whereas in SLI group ΔCBV showed similar values during the whole period of 15 minutes. Comparing both groups within the first 15 minutes ΔCBV showed a tendency toward different overall courses (p = 0.051). This is the first study demonstrating an impact of SLI on CBV. Further studies are warranted including reconfirmation of the present findings in infants with lower gestational age. Future investigations on SLI should not only focus on respiratory outcome but also on the consequences on the developing brain. German Clinical Trials Register DRKS00005161
Find related publications in this database (using NLM MeSH Indexing)
Blood Volume -
Brain - blood supply
Humans -
Infant, Newborn -
Infant, Premature -
Lung - physiopathology
Oxygen - metabolism
Oxygen Inhalation Therapy - methods
Pilot Projects -
Respiration, Artificial - methods
Respiratory Distress Syndrome, Newborn - physiopathology
Resuscitation -

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