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Krenn-Pilko, S; Langsenlehner, U; Stojakovic, T; Pichler, M; Gerger, A; Kapp, KS; Langsenlehner, T.
An elevated preoperative plasma fibrinogen level is associated with poor disease-specific and overall survival in breast cancer patients.
Breast. 2015; 24(5):667-672 Doi: 10.1016/j.breast.2015.08.003 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Krenn-Pilko Sabine
Langsenlehner Tanja
Co-Autor*innen der Med Uni Graz
Gerger Armin
Kapp Karin S.
Langsenlehner Uwe
Pichler Martin
Stojakovic Tatjana

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Plasma fibrinogen plays an important role in the pathophysiology of tumor cell invasion and metastases. High plasma fibrinogen levels have been associated with poor prognosis in different types of cancer. In the present study, we evaluated the prognostic significance of the preoperative plasma fibrinogen level in a large cohort of breast cancer patients. Data from 520 consecutive breast cancer patients, treated between 1999 and 2004, were evaluated. Disease-specific survival (DSS), overall survival (OS), and distant metastasis-free survival (DMFS) were assessed using Kaplan-Meier curves. To evaluate the independent prognostic significance of fibrinogen, multivariable Cox regression models were applied. The influence of fibrinogen on the predictive accuracy was further determined by the Harrell's c-index. Univariable analysis revealed a significant association between an elevated plasma fibrinogen level and DSS (hazard ratio (HR) 1.70, 95% CI 1.07-2.76, p = 0.026) that remained significant in multivariable analysis (HR 1.71, 95% CI 1.02-2.85; p = 0.042). An increased fibrinogen level was also significantly associated with decreased OS in univariable (HR 1.71, 95% CI 1.11-2.64, p = 0.015) and multivariable analysis (HR 1.62, 95% CI 1.01-2.61; p = 0.048). In patients with ER/PR+, HER2- tumors, plasma fibrinogen was associated with DSS in univariable (HR 2.65, 95% CI 1.15-6.14, p = 0.023) and multivariable analysis (HR 3.63, 95% CI 1.37-9.64, p = 0.010). Furthermore, in those patients, the estimated c-index of the multivariable model for DSS was 0.755 without fibrinogen and 0.785 when fibrinogen was added. An elevated preoperative plasma fibrinogen level may represent an independent prognostic marker for survival in breast cancer patients. Copyright © 2015 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Biomarkers, Tumor - blood
Breast Neoplasms - blood
Breast Neoplasms - mortality
Breast Neoplasms - surgery
Female -
Fibrinogen - metabolism
Follow-Up Studies -
Humans -
Kaplan-Meier Estimate -
Middle Aged -
Predictive Value of Tests -
Preoperative Period -
Prognosis -
Proportional Hazards Models -
Receptor, ErbB-2 - analysis
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Retrospective Studies -
Survival Rate -

Find related publications in this database (Keywords)
Breast cancer
Prognostic factors
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