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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Birner, A; Seiler, S; Lackner, N; Bengesser, SA; Queissner, R; Fellendorf, FT; Platzer, M; Ropele, S; Enzinger, C; Schwingenschuh, P; Mangge, H; Pirpamer, L; Deutschmann, H; McIntyre, RS; Kapfhammer, HP; Reininghaus, B; Reininghaus, EZ.
Cerebral White Matter Lesions and Affective Episodes Correlate in Male Individuals with Bipolar Disorder.
PLoS One. 2015; 10(8):e0135313-e0135313 Doi: 10.1371/journal.pone.0135313 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Birner Armin
Seiler Stephan
Co-Autor*innen der Med Uni Graz
Bengesser Susanne
Dalkner Nina
Deutschmann Hannes
Enzinger Christian
Fellendorf Frederike
Kapfhammer Hans-Peter
Mangge Harald
Pirpamer Lukas
Platzer Martina
Queissner Robert
Reininghaus Bernd
Reininghaus Eva
Ropele Stefan
Schwingenschuh Petra

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Cerebral white matter lesions (WML) have been found in normal aging, vascular disease and several neuropsychiatric conditions. Correlations of WML with clinical parameters in BD have been described, but not with the number of affective episodes, illness duration, age of onset and Body Mass Index in a well characterized group of euthymic bipolar adults. Herein, we aimed to evaluate the associations between bipolar course of illness parameters and WML measured with volumetric analysis. In a cross-sectional study 100 euthymic individuals with BD as well as 54 healthy controls (HC) were enrolled to undergo brain magnetic resonance imaging using 3T including a FLAIR sequence for volumetric assessment of WML-load using FSL-software. Additionally, clinical characteristics and psychometric measures including Structured Clinical Interview according to DSM-IV, Hamilton-Depression, Young Mania Rating Scale and Beck's Depression Inventory were evaluated. Individuals with BD had significantly more (F = 3.968, p < .05) WML (Mdn = 3710 mm3; IQR = 2961 mm3) than HC (Mdn = 2185 mm3; IQR = 1665 mm3). BD men (Mdn = 4095 mm3; IQR = 3295 mm3) and BD women (Mdn = 3032 mm3; IQR = 2816 mm3) did not significantly differ as to the WML-load or the number and type of risk factors for WML. However, in men only, the number of manic/hypomanic episodes (r = 0.72; p < .001) as well as depressive episodes (r = 0.51; p < .001) correlated positively with WML-load. WML-load strongly correlated with the number of manic episodes in male BD patients, suggesting that men might be more vulnerable to mania in the context of cerebral white matter changes.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Bipolar Disorder - physiopathology
Body Mass Index -
Brain - pathology
Case-Control Studies -
Cross-Sectional Studies -
Depression -
Female -
Humans -
Life Style -
Magnetic Resonance Imaging -
Male -
Middle Aged -
Psychometrics -
Sex Factors -
Software -
Surveys and Questionnaires -
White Matter - abnormalities

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