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Krenn-Pilko, S; Langsenlehner, U; Stojakovic, T; Pichler, M; Gerger, A; Kapp, KS; Langsenlehner, T.
The elevated preoperative derived neutrophil-to-lymphocyte ratio predicts poor clinical outcome in breast cancer patients.
Tumour Biol. 2016; 37(1):361-368 Doi: 10.1007/s13277-015-3805-4 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Krenn-Pilko Sabine
Langsenlehner Tanja
Co-Autor*innen der Med Uni Graz
Gerger Armin
Kapp Karin S.
Langsenlehner Uwe
Pichler Martin
Stojakovic Tatjana

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Existing preclinical and clinical data suggest that the presence of a systemic inflammatory response plays a critical role in the progression of several solid tumors. The derived neutrophil-to-lymphocyte ratio (dNLR) represents an easily determinable marker of systemic inflammation and has been proposed as a potential prognostic marker. The present study was performed to validate and further clarify the prognostic relevance of an elevated pre-treatment dNLR in a large cohort of European breast cancer patients. Data from 762 consecutive female breast cancer patients treated from 1999 to 2004 were evaluated. Disease-free survival (DFS) and overall survival (OS) were assessed using the Kaplan-Meier method. To evaluate the prognostic relevance, univariate and multivariate Cox regression models were performed for each endpoint. Applying receiver operating characteristics (ROC) analysis, the optimal cutoff level for the dNLR was 3. In univariate analysis, a dNLR ≥3 was associated with poor DFS (hazard ratio (HR) 1.87, 95 % confidence interval (CI) 1.28-2.73, p = 0.001) and OS (HR 1.67, 95 % CI 1.07-2.63, p = 0.025). Multivariate analysis revealed a significant association between the elevated dNLR and poor DFS (hazard ratio (HR) 1.70, 95 % CI 1.09-2.65, p = 0.018) but did not show a significant association between the dNLR and OS (HR 1.54, 95 % CI 0.91-2.59, p = 0.106). The present study shows that the pre-treatment dNLR is an independent prognostic factor that could be useful for future individual risk assessment in breast cancer patients.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Breast Neoplasms - blood
Breast Neoplasms - diagnosis
Breast Neoplasms - metabolism
Breast Neoplasms - surgery
Cohort Studies -
Disease-Free Survival -
Female -
Follow-Up Studies -
Humans -
In Situ Hybridization, Fluorescence -
Inflammation -
Lymphocyte Count -
Lymphocytes - cytology
Male -
Middle Aged -
Multivariate Analysis -
Neutrophils - cytology
Preoperative Period -
Prognosis -
Proportional Hazards Models -
ROC Curve -
Risk Assessment -
Treatment Outcome -

Find related publications in this database (Keywords)
Breast cancer
Derived neutrophil-to-lymphocyte ratio
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