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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Lackner, N; Bengesser, SA; Birner, A; Painold, A; Fellendorf, FT; Platzer, M; Reininghaus, B; Weiss, EM; Mangge, H; McIntyre, RS; Fuchs, D; Kapfhammer, HP; Wallner-Liebmann, SJ; Reininghaus, EZ.
Abdominal obesity is associated with impaired cognitive function in euthymic bipolar individuals.
World J Biol Psychiatry. 2016; 17(7):535-546 Doi: 10.3109/15622975.2015.1046917
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Führende Autor*innen der Med Uni Graz
Bengesser Susanne
Dalkner Nina
Co-Autor*innen der Med Uni Graz
Birner Armin
Fellendorf Frederike
Holasek Sandra Johanna
Kapfhammer Hans-Peter
Mangge Harald
Painold Annamaria
Platzer Martina
Reininghaus Bernd
Reininghaus Eva

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Overweight/obesity has been implicated to play a role in cognitive deficits in bipolar disorder (BD). This study aims to identify the relationship between body fat distribution and different domains of cognition in BD during euthymia. A sample of 100 euthymic individuals with BD was measured with a cognitive test battery (i.e., Trail Making Test-A-B/TM-A/B, d2 Test of Attention, Stroop test, California Verbal Learning Test/CVLT) and an anthropometric measures set (body mass index, waist circumference, hip circumference, waist-to-hip-ratio, waist-to-height-ratio, and lipometry). Patient data were compared with a healthy control group (n = 64). Results show that overweight patients with BD exhibit lower performance in the TMT-A/B as well as in the free recall performance of the CVLT compared to normal-weight patients with BD and controls. In bipolar individuals, (abdominal) obesity was significantly associated with a poor cognitive performance. In bipolar females, associations with measures of verbal learning and memory were found; in bipolar males, associations with poor performance in the TMT-A/B and in the Stroop interference task were demonstrated. In controls, no associations were found. There are several possible pathways moderating the association between obesity and cognition in BD. Anthropometric and lipometry data underline the substantial mediating impact of body fat distribution on cognition in BD.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Attention -
Austria -
Bipolar Disorder - complications
Body Fat Distribution -
Case-Control Studies -
Cognition -
Cognition Disorders - epidemiology
Cognition Disorders - psychology
Executive Function -
Female -
Humans -
Male -
Memory -
Middle Aged -
Multivariate Analysis -
Neuropsychological Tests -
Obesity, Abdominal - epidemiology
Overweight - epidemiology
Psychiatric Status Rating Scales -
Sex Characteristics -
Verbal Learning -

Find related publications in this database (Keywords)
bipolar disorder
body fat distribution
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