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SHR Neuro Krebs Kardio Lipid

Szkandera, J; Gerger, A; Liegl-Atzwanger, B; Stotz, M; Samonigg, H; Friesenbichler, J; Stojakovic, T; Leithner, A; Pichler, M.
The derived neutrophil/lymphocyte ratio predicts poor clinical outcome in soft tissue sarcoma patients.
Am J Surg. 2015; 210(1): 111-116.
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Autor/innen der Med Uni Graz:
Friesenbichler Jörg
Gerger Armin
Leithner Andreas
Liegl-Atzwanger Bernadette
Pichler Martin
Samonigg Hellmut
Stojakovic Tatjana
Stotz Michael
Szkandera Joanna

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Inflammation plays an important role in tumor proliferation and survival in cancer patients. The aim of this study was to investigate the prognostic impact of the pre-operative-derived neutrophil/lymphocyte ratio (dNLR) in a large cohort of soft tissue sarcoma (STS) patients after curative surgical resection. The impact of preoperative dNLR on disease-free survival (DFS) and overall survival (OS) in retrospectively evaluated 340 STS patients was assessed using Kaplan-Meier curves and Cox proportional models. Applying receiver operating curve analysis, we determined a cut-off value of 2.39 for the dNLR to be optimal for discrimination of patients' survival in the whole cohort. Kaplan-Meier curves revealed a dNLR greater than or equal to 2.39 as a marker for decreased DFS (P = .031) and OS (P = .007, log-rank test) in STS patients. In multivariate analysis, increased dNLR was significantly associated with poor OS (hazard ratio 1.60, 95% confidence interval 1.07 to 2.40, P = .022). This study demonstrates that preoperative dNLR might represent a well-correlated surrogate marker for the widely validated NLR. The dNLR is easily obtainable and can provide important information for individual risk assessment in clinical trials. Copyright © 2015 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Disease-Free Survival -
Female -
Humans -
Leukocyte Count -
Lymphocytes -
Male -
Middle Aged -
Neutrophils -
Predictive Value of Tests -
Retrospective Studies -
Sarcoma - blood Sarcoma - surgery
Soft Tissue Neoplasms - blood Soft Tissue Neoplasms - surgery
Treatment Outcome -

Find related publications in this database (Keywords)
Derived neutrophil/lymphocyte ratio
Soft tissue sarcoma
Prognostic marker
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