Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szkandera, J; Gerger, A; Liegl-Atzwanger, B; Stotz, M; Samonigg, H; Ploner, F; Stojakovic, T; Gary, T; Leithner, A; Pichler, M.
Uric acid levels in blood are associated with clinical outcome in soft-tissue sarcoma patients.
Clin Chem Lab Med. 2015; 53(3):493-497
Doi: 10.1515/cclm-2014-0486
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Pichler Martin
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Gary Thomas
- Gerger Armin
- Leithner Andreas
- Liegl-Atzwanger Bernadette
- Ploner Ferdinand
- Samonigg Hellmut
- Stojakovic Tatjana
- Stotz Michael
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- Abstract:
- Recent evidence indicates toward a role of uric acid (UA) as a potential antioxidant. Elevated UA levels were shown to be associated with better survival in various malignancies. The aim of the present study was to evaluate the prognostic relevance of pre-operative UA levels on cancer-specific survival (CSS) in soft-tissue sarcoma (STS) patients who underwent curative surgical resection. Three hundred and fifty-seven patients with STS were included in the study. Pre-operative serum UA level was measured using an enzymatic colorimetric assay. The effect of UA levels on CSS was analyzed using Kaplan-Meier curves. To further evaluate the prognostic impact of UA levels, univariate and multivariate Cox proportional models were calculated. Among the 357 STS patients, cancer-related deaths occurred in 20 (24.7%) of 81 patients with a serum UA level <279.6 µmol/L and in 36 (13%) of 276 patients with a UA level ≥279.6 µmol/L. In univariate analysis, elevated UA levels were significantly associated with increased CSS in STS patients [hazard ratio (HR) 0.44, 95% confidence interval (CI) 0.26-0.77, p=0.004]. Furthermore, elevated UA levels remain a significant factor for better CCS in multivariate analysis (HR 0.42, 95% CI 0.23-0.75, p=0.003). Our study is the first one to demonstrate that higher UA levels are associated with positive clinical outcome in STS patients. UA levels are a simple and cost-effective test for the assessment of the prognosis of STS patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
- ROC Curve -
- Sarcoma - blood
- Sarcoma - diagnosis
- Sarcoma - therapy
- Treatment Outcome -
- Uric Acid - blood
- Find related publications in this database (Keywords)
- prognostic marker
- soft-tissue sarcoma
- uric acid levels