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Szkandera, J; Gerger, A; Liegl-Atzwanger, B; Stotz, M; Samonigg, H; Ploner, F; Stojakovic, T; Leithner, A; Pichler, M.
Pre-treatment anemia is a poor prognostic factor in soft tissue sarcoma patients.
PLoS One. 2014; 9(9):e107297-e107297 Doi: 10.1371/journal.pone.0107297 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Pichler Martin
Szkandera Joanna
Co-Autor*innen der Med Uni Graz
Gerger Armin
Leithner Andreas
Liegl-Atzwanger Bernadette
Ploner Ferdinand
Samonigg Hellmut
Stojakovic Tatjana
Stotz Michael

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Anemia refers to low hemoglobin (Hb) levels, represents a common symptom and complication in cancer patients and was reported to negatively influence survival in patients with various malignancies. In the present study, we aimed to explore the prognostic impact of pre-operative Hb levels on clinical outcome in a large cohort of soft tissue sarcoma (STS) patients after curative surgery. Retrospective data from 367 STS patients, which were operated between 1998 and 2013, were included in the study. Cut-off levels for anemia were defined as Hb<13 g/dl in males and Hb<12 g/dl in females according to the current WHO guidelines. The impact of pre-operative Hb levels on cancer-specific survival (CSS) and overall survival (OS) was assessed using Kaplan-Meier curves. Additionally, Hb levels were compared for the prognostic influence on CSS and OS applying univariate and multivariate Cox proportional models. Hb level was associated with established prognostic factors, including age, tumor grade, size and depth (p<0.05). Kaplan-Meier curves showed that low Hb levels were significantly associated with decreased CSS and OS in STS patients (p<0.001 for both endpoints, log-rank test). In multivariate analysis, we found an independent association between low Hb levels and poor CSS and OS (HR = 0.46, Cl 95% = 0.25-0.85, p = 0.012; HR = 0.34, Cl 95% = 0.23-0.51, p<0.001). The present data underline a negative prognostic impact of low pre-operative Hb levels on clinical outcome in STS patients. Thus, Hb levels may provide an additional and cost-effective tool to discriminate between STS patients that are at high risk of mortality.
Find related publications in this database (using NLM MeSH Indexing)
Age Factors -
Aged -
Anemia - blood
Biomarkers - blood
Female -
Hemoglobins - deficiency
Humans -
Male -
Middle Aged -
Neoplasm Grading -
Prognosis -
Proportional Hazards Models -
Retrospective Studies -
Sarcoma - blood
Survival Analysis -

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