Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Amrein, K; Dobnig, H; Wagner, D; Piswanger-Sölkner, C; Pieber, TR; Pilz, S; Tomaschitz, A; Dimai, HP; Fahrleitner-Pammer, A.
Sclerostin in institutionalized elderly women: associations with quantitative bone ultrasound, bone turnover, fractures, and mortality.
J Am Geriatr Soc. 2014; 62(6):1023-1029
Doi: 10.1111/jgs.12791
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Amrein Karin
- Co-Autor*innen der Med Uni Graz
- Dimai Hans Peter
- Dobnig Harald
- Fahrleitner-Pammer Astrid
- Pieber Thomas
- Pilz Stefan
- Piswanger-Solkner Claudia
- Tomaschitz Andreas
- Wagner Doris
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- Abstract:
- To evaluate the association between levels of circulating sclerostin (an emerging biomarker and important regulator of bone formation) and laboratory parameters of bone and mineral metabolism, bone mineral density and quality measured using quantitative ultrasound (QUS), fracture risk, and mortality. Prospective cohort study. Austrian nursing homes (N = 95). Female nursing home residents aged 70 and older (mean 84 ± 6; N = 539). Serum sclerostin, bone turnover markers, and bone mineral density and quality were measured at baseline. Participants were followed for clinical fractures and all-cause mortality. Partial correlation analysis adjusted for age, weight, and renal function revealed a significant positive correlation between sclerostin levels and calcaneal stiffness and radial and phalangeal speed of sound (all P < .01) and a significant negative correlation between sclerostin levels and osteocalcin, serum C-terminal telopeptide of type I collagen, and parathyroid hormone (PTH; P < .05). After a mean follow-up of 27 ± 8 months, 139 participants (26%) had died and 64 had a hip or other nonvertebral fracture (12%). Sclerostin was not predictive of mortality. In women with a negative fracture history, it was significantly but not linearly associated with fracture risk. In institutionalized elderly women, there is a significant relationship between serum sclerostin levels and QUS indices, bone turnover, and PTH, but sclerostin was not strongly associated with important clinical outcomes. Thus, it remains unclear whether sclerostin is a clinically useful predictor of fractures or mortality, at least in this setting. © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Bone Density -
- Bone Morphogenetic Proteins - blood
- Bone and Bones - metabolism Bone and Bones - ultrasonography
- Female -
- Fractures, Bone - blood Fractures, Bone - metabolism Fractures, Bone - mortality Fractures, Bone - ultrasonography
- Genetic Markers -
- Humans -
- Institutionalization -
- Prospective Studies -
- Risk Assessment -
- Find related publications in this database (Keywords)
- sclerostin
- fracture risk
- bone turnover
- nursing home
- mortality