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SHR Neuro Krebs Kardio Lipid

Sadoghi, P; Lohberger, B; Aigner, B; Kaltenegger, H; Friesenbichler, J; Wolf, M; Sununu, T; Leithner, A; Vavken, P.
Effect of platelet-rich plasma on the biologic activity of the human rotator-cuff fibroblasts: A controlled in vitro study.
J Orthop Res. 2013; 31(8):1249-1253 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Friesenbichler Jörg
Kaltenegger Heike
Leithner Andreas
Lohberger Birgit
Sadoghi Birgit
Sadoghi Patrick
Wolf Matthias

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To assess the in vitro effect of platelet-rich plasma (PRP) on biological activity of the human rotator cuff fibroblasts and to describe the optimal dose-response to maximize cellular stimulation while reducing potential risk. Rotator cuff (RC) fibroblasts of n = 6 patients (mean age of 65.2 years) undergoing arthroscopic cuff tear reconstruction were cultured in vitro for 21 days and stimulated with PRP in three different concentrations (1-, 5-, and 10-fold). Samples were obtained for DNA and GAG measurement at 1, 7, 14, and 21 days. The biological outcomes were regressed on the PRP concentration. The application of PRP significantly influenced the fibroblast proliferation and activity of the human rotator cuff with elevated glycosaminoglycan (GAG) and DNA levels. The dosage of PRP had the significantly highest impact on this proliferation using a onefold or fivefold application. PRP has a significant effect on fibroblast proliferation of the human rotator cuff in vitro with an optimal benefit using a onefold or fivefold PRP concentration. This study justifies further in vivo investigations using PRP at the human rotator cuff.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Cell Proliferation - drug effects
Cells, Cultured -
DNA - analysis
Dose-Response Relationship, Drug -
Fibroblasts - cytology
Glycosaminoglycans - metabolism
Humans -
Middle Aged -
Platelet-Rich Plasma - physiology
Rotator Cuff - cytology

Find related publications in this database (Keywords)
in vivo study
biological activity
rotator cuff
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