Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fischerauer, EE; Manninger, M; Seles, M; Janezic, G; Pichler, K; Ebner, B; Weinberg, AM.
BMP-6 and BMPR-1a are up-regulated in the growth plate of the fractured tibia.
J Orthop Res. 2013; 31(3):357-363
Doi: 10.1002/jor.22238
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- Führende Autor*innen der Med Uni Graz
- Amerstorfer Eva
- Co-Autor*innen der Med Uni Graz
- Gallé Birgit
- Manninger-Wünscher Martin
- Pichler Karin
- Seles Maximilian
- Weinberg Annelie-Martina
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- Abstract:
- Bone overgrowth is a known phenomenon occurring after fracture of growing long bones with possible long-term physical consequences for affected children. Here, the physeal expression of bone morphogenetic proteins (BMPs) was investigated in a fracture-animal model to test the hypothesis that a diaphyseal fracture stimulates the physeal expression of these known key regulators of bone formation, thus stimulating bone overgrowth. Sprague-Dawley rats (male, 4 weeks old), were subjected to a unilateral mid-diaphyseal tibial fracture. Kinetic expression of physeal BMP-2, -4, -6, -7, and BMP receptor-1a (BMPR-1a) was analyzed in a monthly period by quantitative real time-polymerase chain reaction and immunohistochemistry. On Days 1, 3, 10, and 14 post-fracture, no changes in physeal BMPs gene-expression were detected. Twenty-nine days post-fracture, when the fracture was consolidated, physeal expression of BMP-6 and BMPR-1a was significantly upregulated in the growth plate of the fractured and contra-lateral intact bone compared to control (p<0.005). This study demonstrates a late role of BMP-6 and BMPR-1a in fracture-induced physeal growth alterations and furthermore, may have discovered the existence of a regulatory "cross-talk" mechanism between the lower limbs whose function could be to limit leg-length-discrepancies following the breakage of growing bones. Copyright © 2012 Orthopaedic Research Society.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bone Morphogenetic Protein 2 - genetics
- Bone Morphogenetic Protein 4 - genetics
- Bone Morphogenetic Protein 6 - genetics
- Bone Morphogenetic Protein 7 - genetics
- Bone Morphogenetic Protein Receptors, Type I - genetics
- Chondrocytes - physiology
- Diaphyses - injuries
- Fracture Healing - physiology
- Growth Plate - injuries
- Male -
- Rats -
- Rats, Sprague-Dawley -
- Tibia - injuries
- Tibial Fractures - genetics
- Up-Regulation - physiology
- Find related publications in this database (Keywords)
- growth plate
- fracture healing
- bone morphogenetic proteins
- overgrowth
- chondrocytes