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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fischerauer, EE; Manninger, M; Seles, M; Janezic, G; Pichler, K; Ebner, B; Weinberg, AM.
BMP-6 and BMPR-1a are up-regulated in the growth plate of the fractured tibia.
J Orthop Res. 2013; 31(3):357-363 Doi: 10.1002/jor.22238 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Amerstorfer Eva
Co-Autor*innen der Med Uni Graz
Gallé Birgit
Manninger-Wünscher Martin
Pichler Karin
Seles Maximilian
Weinberg Annelie-Martina

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Bone overgrowth is a known phenomenon occurring after fracture of growing long bones with possible long-term physical consequences for affected children. Here, the physeal expression of bone morphogenetic proteins (BMPs) was investigated in a fracture-animal model to test the hypothesis that a diaphyseal fracture stimulates the physeal expression of these known key regulators of bone formation, thus stimulating bone overgrowth. Sprague-Dawley rats (male, 4 weeks old), were subjected to a unilateral mid-diaphyseal tibial fracture. Kinetic expression of physeal BMP-2, -4, -6, -7, and BMP receptor-1a (BMPR-1a) was analyzed in a monthly period by quantitative real time-polymerase chain reaction and immunohistochemistry. On Days 1, 3, 10, and 14 post-fracture, no changes in physeal BMPs gene-expression were detected. Twenty-nine days post-fracture, when the fracture was consolidated, physeal expression of BMP-6 and BMPR-1a was significantly upregulated in the growth plate of the fractured and contra-lateral intact bone compared to control (p<0.005). This study demonstrates a late role of BMP-6 and BMPR-1a in fracture-induced physeal growth alterations and furthermore, may have discovered the existence of a regulatory "cross-talk" mechanism between the lower limbs whose function could be to limit leg-length-discrepancies following the breakage of growing bones. Copyright © 2012 Orthopaedic Research Society.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Bone Morphogenetic Protein 2 - genetics
Bone Morphogenetic Protein 4 - genetics
Bone Morphogenetic Protein 6 - genetics
Bone Morphogenetic Protein 7 - genetics
Bone Morphogenetic Protein Receptors, Type I - genetics
Chondrocytes - physiology
Diaphyses - injuries
Fracture Healing - physiology
Growth Plate - injuries
Male -
Rats -
Rats, Sprague-Dawley -
Tibia - injuries
Tibial Fractures - genetics
Up-Regulation - physiology

Find related publications in this database (Keywords)
growth plate
fracture healing
bone morphogenetic proteins
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