Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wackernagel, W; Holl, E; Tarmann, L; Avian, A; Schneider, MR; Kapp, K; Langmann, G.
Visual acuity after Gamma-Knife radiosurgery of choroidal melanomas.
Br J Ophthalmol. 2013; 97(2):153-158
Doi: 10.1136/bjophthalmol-2012-302399
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Wackernagel Werner
- Co-Autor*innen der Med Uni Graz
- Avian Alexander
- Holl Etienne
- Kapp Karin S.
- Langmann Gerald
- Schneider Mona Regina
- Vajda Lisa
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- Abstract:
- To report on conservation of visual acuity after Gamma-Knife radiosurgery of choroidal melanoma. A total of 189 patients with choroidal melanoma were treated with Gamma-Knife stereotactic single-fraction radiosurgery at a single institution between June 1992 and May 2010. The main outcome measure of our retrospective analysis was conservation of pretreatment visual acuity of 20/40 or better, 20/200 or better and counting fingers (CF) or better, over time of follow-up. Patient, tumour and treatment parameters were evaluated as potential risk factors for visual loss. Five years after treatment, the actuarial probability of keeping visual acuity better than 20/40, 20/200 and CF was 13%, 14% and 36%, respectively. The majority of patients (84.7%) encountered a deterioration of vision after treatment. The most important risk factors for visual loss were tumour height, longest basal diameter, distance to the optic disk and/or foveola, and retinal detachment before treatment. Treatment dose, and patient characteristics (age, sex, concurrent systemic diseases) were less important. Local tumour control rate was 94.4% after a median follow-up of 39.5 months. Visual outcome after single-fraction Gamma-Knife radiotherapy is comparable with linear accelerator (LINAC) based fractionated stereotactic radiotherapy, inferior to proton beam radiotherapy, and depends primarily on tumour size, location and pre-existing retinal detachment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Child -
- Choroid Neoplasms - physiopathology
- Choroid Neoplasms - surgery
- Female -
- Follow-Up Studies -
- Humans -
- Male -
- Melanoma - physiopathology
- Melanoma - surgery
- Middle Aged -
- Postoperative Period -
- Radiosurgery - methods
- Retrospective Studies -
- Treatment Outcome -
- Visual Acuity -
- Young Adult -