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Wackernagel, W; Holl, E; Tarmann, L; Avian, A; Schneider, MR; Kapp, K; Langmann, G.
Visual acuity after Gamma-Knife radiosurgery of choroidal melanomas.
Br J Ophthalmol. 2013; 97(2):153-158 Doi: 10.1136/bjophthalmol-2012-302399
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Führende Autor*innen der Med Uni Graz
Wackernagel Werner
Co-Autor*innen der Med Uni Graz
Avian Alexander
Holl Etienne
Kapp Karin S.
Langmann Gerald
Schneider Mona Regina
Vajda Lisa

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To report on conservation of visual acuity after Gamma-Knife radiosurgery of choroidal melanoma. A total of 189 patients with choroidal melanoma were treated with Gamma-Knife stereotactic single-fraction radiosurgery at a single institution between June 1992 and May 2010. The main outcome measure of our retrospective analysis was conservation of pretreatment visual acuity of 20/40 or better, 20/200 or better and counting fingers (CF) or better, over time of follow-up. Patient, tumour and treatment parameters were evaluated as potential risk factors for visual loss. Five years after treatment, the actuarial probability of keeping visual acuity better than 20/40, 20/200 and CF was 13%, 14% and 36%, respectively. The majority of patients (84.7%) encountered a deterioration of vision after treatment. The most important risk factors for visual loss were tumour height, longest basal diameter, distance to the optic disk and/or foveola, and retinal detachment before treatment. Treatment dose, and patient characteristics (age, sex, concurrent systemic diseases) were less important. Local tumour control rate was 94.4% after a median follow-up of 39.5 months. Visual outcome after single-fraction Gamma-Knife radiotherapy is comparable with linear accelerator (LINAC) based fractionated stereotactic radiotherapy, inferior to proton beam radiotherapy, and depends primarily on tumour size, location and pre-existing retinal detachment.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Child -
Choroid Neoplasms - physiopathology
Choroid Neoplasms - surgery
Female -
Follow-Up Studies -
Humans -
Male -
Melanoma - physiopathology
Melanoma - surgery
Middle Aged -
Postoperative Period -
Radiosurgery - methods
Retrospective Studies -
Treatment Outcome -
Visual Acuity -
Young Adult -

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