Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szkandera, J; Absenger, G; Stotz, M; Weissmueller, M; Winder, T; Langsenlehner, T; Samonigg, H; Renner, W; Schippinger, W; Gerger, A.
The Functional Polymorphism of Erythropoietin Gene rs1617640 G>T Is Not Associated with Susceptibility and Clinical Outcome of Early-stage Breast Cancer.
Anticancer Res. 2012; 32(8):3473-3478
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Gerger Armin
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Absenger Gudrun
- Langsenlehner Tanja
- Renner Wilfried
- Samonigg Hellmut
- Schippinger Walter
- Stotz Michael
- Weissmüller Melanie
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- Abstract:
- Recent data suggest that erythropoietin (EPO) plays a substantial role in cancer development and clinical outcome by stimulating cell proliferation, invasion and angiogenesis. A functional polymorphism (rs1617640 G>T) in the promoter region of the EPO gene increases EPO protein expression. In the present study, we investigated the association of EPO rs1617640 G>T with susceptibility and clinical outcome of early-stage breast cancer. Genomic DNA of 539 female patients with histologically confirmed early-stage breast cancer and 804 controls was genotyped for EPO rs1617640 G>T. No association was found between EPO rs1617640 G>T and early-stage breast cancer susceptibility and clinical outcome (hazard ratio=1.24, 95% confidence interval=1.82-1.90, p=0.31). In conclusion, our findings suggest a lack of influence of EPO rs1617640 G>T on early-stage breast carcinogenesis and clinical outcome.
- Find related publications in this database (using NLM MeSH Indexing)
- Breast Neoplasms - genetics Breast Neoplasms - pathology
- Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology
- Erythropoietin - genetics
- Female -
- Genetic Predisposition to Disease -
- Humans -
- Polymorphism, Genetic -
- Promoter Regions, Genetic -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Breast cancer
- germline polymorphism
- erythropoietin