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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Szkandera, J; Absenger, G; Stotz, M; Weissmueller, M; Winder, T; Langsenlehner, T; Samonigg, H; Renner, W; Schippinger, W; Gerger, A.
The Functional Polymorphism of Erythropoietin Gene rs1617640 G>T Is Not Associated with Susceptibility and Clinical Outcome of Early-stage Breast Cancer.
Anticancer Res. 2012; 32(8):3473-3478
Web of Science PubMed


Führende Autor*innen der Med Uni Graz
Gerger Armin
Szkandera Joanna
Co-Autor*innen der Med Uni Graz
Absenger Gudrun
Langsenlehner Tanja
Renner Wilfried
Samonigg Hellmut
Schippinger Walter
Stotz Michael
Weissmüller Melanie

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Plum Analytics:
Recent data suggest that erythropoietin (EPO) plays a substantial role in cancer development and clinical outcome by stimulating cell proliferation, invasion and angiogenesis. A functional polymorphism (rs1617640 G>T) in the promoter region of the EPO gene increases EPO protein expression. In the present study, we investigated the association of EPO rs1617640 G>T with susceptibility and clinical outcome of early-stage breast cancer. Genomic DNA of 539 female patients with histologically confirmed early-stage breast cancer and 804 controls was genotyped for EPO rs1617640 G>T. No association was found between EPO rs1617640 G>T and early-stage breast cancer susceptibility and clinical outcome (hazard ratio=1.24, 95% confidence interval=1.82-1.90, p=0.31). In conclusion, our findings suggest a lack of influence of EPO rs1617640 G>T on early-stage breast carcinogenesis and clinical outcome.
Find related publications in this database (using NLM MeSH Indexing)
Breast Neoplasms - genetics Breast Neoplasms - pathology
Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology
Erythropoietin - genetics
Female -
Genetic Predisposition to Disease -
Humans -
Polymorphism, Genetic -
Promoter Regions, Genetic -
Treatment Outcome -

Find related publications in this database (Keywords)
Breast cancer
germline polymorphism
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